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Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration

A-Synuclein, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Oral Microbiome, Parkinson's Disease, Pre-PD /

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Creutzfeldt–Jakob disease (CJD) are brain conditions affecting millions of people worldwide. These diseases are associated with the presence of amyloid-β (Aβ), alpha synuclein (α-Syn) and prion protein (PrP) depositions in the brain, respectively, which lead to synaptic disconnection and subsequent progressive neuronal death. Although […]

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Gut Health Guide; Essential Oils Protocol

Gut Dysbiosis, Gut Permeability / Leaky Gut, Herbs & Spices, Parkinson's Disease /

IntroductionThere’s a reason we shorten the Standard American Diet to S-A-D. Never has amore fitting abbreviation been seen in the health industry. Our food, and theway our body processes that food, impacts our health in profound ways.And, it all starts in the gut.Put simply, when our gut isn’t healthy and happy, nothing about our bodies

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From the intestinal mucosal barrier to the enteric neuromuscular compartment: An integrated overview on the morphological changes in Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Non-Motor Symptoms /

Gastrointestinal dysfunctions represent the most common non-motor symptoms in Parkinson’s disease (PD). Ofnote, changes in gut microbiota, impairments of intestinal epithelial barrier (IEB), bowel inflammation and neuroplastic rearrangements of the enteric nervous system (ENS) could be involved in the pathophysiology of theintestinal disturbances in PD. In this context, although several review articles have pooled together

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Potential Role of Akkermansia muciniphila in Parkinson’s Disease and Other Neurological/Autoimmune Diseases

Gut Microbiota, Metabolites, Probiotics, Prebiotics and Symbiotics /

The composition of the gut microbiota, including Akkermansia muciniphila (A. muciniphila), is altered in many neurological diseases and may be involved in the pathophysiological processes of Parkinson’s disease (PD). A. muciniphila, a mucin-degrading bacterium, is a potential next-generation microbe that has anti-inflammatory properties and is responsible for keeping the body healthy. As the role of A. muciniphila in PD has

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Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s diseas

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

The proximity ligation assay (PLA) is a specific and sensitive technique for the detection of αSyn oligomers (αSyn-PLA), early and toxic species implicated in the pathogenesis of PD. We aimed to evaluate by skin biopsy the diagnostic and prognostic capacity of αSyn-PLA and small nerve fiber reduction in PD in a longitudinal study. αSyn-PLA was

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Gut Microbiota-Brain Interaction with Special Reference to Alzheimer’s Disease

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Gut microbiota is showing and raising evidence that the dynamic changes in the gut microorganism can influence physiology and behavior of brain. Dysbiosis or dysbacteriosis is a condition of microbial imbalance inside the intestinal microbiome. It has been associated with disorders of intestinal and extra‐intestinal such as inflammatory bowel disease and other multiple diseases like

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The link between the gut microbiota and Parkinson’s Disease: A systematic mechanism review with focus on α-synuclein transport

A-Synuclein, ENS, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD /

Research has suggested a link between the gut microbiota and Parkinson’s Disease (PD), and an early involvement of gastrointestinal dysfunction has been reported in patients. A mechanism review was performed to investigate whether the neurodegenerative cascade begins in the gut; mediated by gut dysbiosis and retrograde transport of α-synuclein. This review provides a summary of

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Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson’s disease

A-Synuclein, Constipation, ENS, Gut Dysbiosis, Gut-Brain axis /

Two hallmarks of Parkinson’s disease (PD) are the widespread deposition of misfolded alpha-synuclein (αSyn) protein in the nervous system and loss of substantia nigra dopamine neurons. Recent research has suggested that αSyn aggregates in the enteric nervous system (ENS) lead to prodromal gastrointestinal (GI) symptoms such as constipation in PD, then propagating to the brain stem and eventually triggering neurodegeneration and

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What is leaky gut? Or… what? You can’t even eat HUMMUS?

Gut Dysbiosis, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD /

So what is intestinal permeability? Intestinal permeability (aka ‘leaky gut’) is the condition where the tight junctions on the lining of the intestine loosen, allowing undigested food particles, environmental toxins, foreign bacteria, and other normally restricted molecules to cross the gut barrier and migrate to other parts of the body. Normally, our intestines push molecules

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Effects of probiotic supplementation on intestinal tight junctions in a mouse model of Parkinson’s disease

Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is a neurological disease impacting over six million people in the world. In addition to the motor symptoms of the disease, the disorder is accompanied with gastrointestinal problems. These include delayed transit time, disturbances in the microbial composition of the gut, inflammation in the intestine, structural changes in the epithelial lining and

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