All smell tests were able to discriminate the olfactory function of PD from that of healthy individuals, although the UPSIT was widely used. The abnormal olfaction was not related to the disease duration. CLICK TO REVIEW
The aggregation of alpha-synuclein (α-Syn) plays a critical role in the development of Parkinson’s disease (PD) and other synucleinopathies. α-Syn, which is encoded by the SNCA gene, is a lysine-rich soluble amphipathic protein normally expressed in neurons. Located in the cytosolic domain, this protein has the ability to remodel itself in plasma membranes, where it
With the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. Besides the consumption of probiotics to stimulate favorable bacterial communities in the human gastrointestinal tract, prebiotics such as inulin-type fructans (ITF)
Bacterial metabolites/proteins can also reduce ɑ-synuclein aggregation in vitro CLICK TO REVIEW POSTER
Strain-level meta-analysis of Parkinson’s disease-associated gut microbiome Read More »
The Mediterranean diet has been associated with the risk of Parkinson’s disease (PD),but limited research has been performed on other dietary patterns. We studied the relationshipbetween overall diet quality and PD risk in the general population. We included 9414 participantsfrom the Rotterdam Study, a prospective population-based study in the Netherlands. Diet wasdefined using a Dutch
Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study Read More »
Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM)sleep behavior disorder (RBD). Although there are current American Academy of SleepMedicine standards to diagnose RBD, several aspects need to be addressed to achieveharmonization across sleep centers. Prodromal RBD is a stage in which symptoms andsigns of evolving RBD are present, but do not yet meet
In recent years, human gut microbiota have become one of the most promising areasof microorganism research; meanwhile, the inter-relation between the gut microbiota and varioushuman diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central nervous system interact through the gut–brain axis, which includesneuronal, immune-mediated and metabolite-mediated pathways.
Sleep disturbance has been reported in up to 88%–98% of Parkinson’s disease patients; various sleep disorders can present even before motor symptoms. Rapid eye movement sleep behavior disorder (RBD), which can lead to violent dream enactment behavior, has a prevalence in Parkinson’s disease of 20% to 50% but best management of the condition is unclear.
Melatonin as first-line treatment for sleep disorders in Parkinson’s disease? Read More »
Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson’s disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high diagnostic accuracy in several PD and other synucleinopathy patient cohorts. However, there has been confusion about αSyn-SAAs for their methodology, nomenclature, and relative accuracies when
Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to follow two overarching patterns: a caudo-rostral pattern with relatively more pathology in the brainstem than in the telencephalon, and an amygdala-centered pattern with the most
Neuropathological evidence of body-first vs. brain-first Lewy body disease Read More »