Rob

Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases

Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

The human digestive tract is the cottage to trillions of live microorganisms, which regulate health and illness. A healthy GM is necessary for preventing microbial growth, body growth, obesity, cancer, diabetes, and enhancing immunity. The equilibrium in GM’s composition and the presence/absence of critical species enable specific responses to be essential for the host’s better […]

Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases Read More »

Iron Neurotoxicity in Parkinson’s Disease

Iron /

Iron plays essential roles in the early development of cognitive processes and in the maintenance of neuronal functions in the mature brain; therefore, neurons have expeditious mechanisms to ensure a readily available iron supply. However, several neurodegenerative diseases present dysregulation of iron homeostasis derived from mitochondrial dysfunction, inflammatory conditions, decreased glutathione levels, and oxidative damage,

Iron Neurotoxicity in Parkinson’s Disease Read More »

Caries and periodontal disease in patients with Parkinson’s disease

Oral Microbiome, Periodontitis /

Parkinson’s disease (PD) has been associated with aging, reduced fine motor skills, and malnutrition caused by eating soft sticky foods and a decreased liquid intake, which may contribute to the onset of caries, periodontal disease, and tooth loss. The objective of this study was to investigate the oral health of 101 patients with PD (mean

Caries and periodontal disease in patients with Parkinson’s disease Read More »

Clinical evaluation of the periodontal health condition and oral health awareness in Parkinson’s disease patients

endondonics, Oral Microbiome, Parkinson's Disease, Periodontitis, Pre-PD /

Objective and background The objectives were to compare periodontal status between subjects with and without Parkinson’s disease (PKD) to determine the influence of PKD on periodontal disease. This study was conducted to evaluate the relationship of periodontal status with severity of PKD. Conclusion There is a need for dental care and encouragement to use plaque

Clinical evaluation of the periodontal health condition and oral health awareness in Parkinson’s disease patients Read More »

Treating chronic diseases by regulating the gut microbiota

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Chronic diseases encompass a wide range of illnesses, ranging from cardiovascular and cerebrovascular diseases, metabolic syndromes to degenerative neurological disorders. Chronic diseases are responsible for most observed morbidity and mortality in the developed countries as well as in some developing countries. The gut microbiota and its metabolites have been associated with the onset and development

Treating chronic diseases by regulating the gut microbiota Read More »

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Metabolites /

The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H2S) and polysulfides, collectively referred to as reactive sulfur species (RSS)

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism Read More »

Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Vitamins / Supplements / Nutraceuticals /

Berberine (BBR), an isoquinoline alkaloid, has been found in many plants, such as Coptis chinensis Franch. and Phellodendron chinense Schneid. Although BBR has a wide spectrum of pharmacological effects, its oral bioavailability is extremely low. In recent years, gut microbiota has emerged as a cynosure to understand the mechanisms of action of herbal compounds. Numerous studies have demonstrated that,

Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine Read More »

Oral, nasal, and gut microbiota in Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Metabolites, Oral Microbiome /

Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease. The purpose of this study was to investigate the link between microbiota composition in important mucosal interfaces (oral, nasal, and intestinal) and PD. Sequencing was undertaken of the V4–V5 region of the 16S ribosomal RNA (rRNA) gene of the microbiome from the oral cavity,

Oral, nasal, and gut microbiota in Parkinson’s disease Read More »

Parkinson’s disease: the nutrition perspective

Diet and Exercise, Parkinson's Disease, Pre-PD /

Parkinson‟s disease (PD) is the second most common neurodegenerative disease after Alzheimer‟sdisease and affects ~1% of the population over the age of 60 years in industrialised countries. Theaim of this review is to examine nutrition in PD across three domains: dietary intake and thedevelopment of PD; whole body metabolism in PD; and the effects of

Parkinson’s disease: the nutrition perspective Read More »

Beta Amyloid, Tau Protein, and Neuroinflammation: An Attempt to Integrate Different Hypotheses of Alzheimer’s Disease Pathogenesis

Biomarkers /

Alzheimer’s disease (AD) is a neurodegenerative disease that inevitably results in dementia and death. Currently, there are no pathogenetically grounded methods for the prevention and treatment of AD, and all current treatment regimens are symptomatic and unable to significantly delay the development of dementia. The accumulation of β-amyloid peptide (Aβ), which is a spontaneous, aggregation-prone,

Beta Amyloid, Tau Protein, and Neuroinflammation: An Attempt to Integrate Different Hypotheses of Alzheimer’s Disease Pathogenesis Read More »