Thoughts – Just maybe we are finding the mechanics behind the 2+ theory of PD which states that 2 or more variables must come about in order PD to progress into diagnosisable PD. Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble […]
I find this article from 2015 as the industry was very concerned regarding the reemergence of the “focal infection theory” (FIT). One must note that the origins of the FIT date all the way back to Socrates – yes pre-Jesus the Greeks knew of the connection between bad teeth and disease. This artcle was published
Endodontic infections and systemic health – where should we go? Read More »
Parkinson’s Disease (PD) is a highly prevalent neurodegenerative disease among olderadults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons of thesubstantia nigra pars compacta and the widespread accumulation of misfolded intracellularα-synuclein (α-syn). Genetic mutations and post-translational modifications, such as α-syn phosphorylation, have been identified among the multiple factors supporting α-syn accrual
The neuropeptide substance P (SP) plays an important role in neurodegenerative disorders, among which Parkinson’s disease (PD). In the present work we have reviewed the involvement of SP and its preferred receptor (NK1-R) in motor and non-motor PD symptoms, in both PD animal models and patients. Despite PD is primarily a motor disorder, non-motor abnormalities,
What Substance P might tell us about the Prognosis and Mechanism of Parkinson’s Disease? Read More »
The lack of an effective treatment for Alzheimer’s disease (AD) stems primarily from incomplete understanding of AD’s causes. A rapidly growing number of scientific reports highlight important roles played by peripheral infections and intestinal bacterial flora in pathological and physiological functions involving the microbiome-intestine-brain axis. The microbiome controls basic aspects of the central nervous system
Gut Microbiome and Alzheimer’s Disease Read More »
Objectives: The objective of this study was to introduce the evidence obtained throughextensive research that periodontitis increases risk of many systemic diseases. Method: Analysis of some oral bacteria (P. gingivalis, T. denticola, T. forsythia, A.actinomycetemcomitans, and F. nucleatum) and its related treatments and mediatorsby the specific methods (western blot, ELISA, etc). Results: This article reviews
The pathogenic mechanism of oral bacteria and treatment with inhibitors Read More »
Alpha-synuclein protein is associated with Parkinson’s disease and is an intrinsically disordered protein (IDP) in solution. The protein consists of three domains: N-terminal domain, NAC domain, and C-terminal domain. In this research, I used the Gaussian accelerated Molecular Dynamics (GaMD) simulations to examine the role of the flanking domains of the protein. My data show
PROTECTIVE ROLE OF THE FLANKING DOMAINS AND MEMBRANE SELECTIVITY IN THE ALPHA-SYNUCLEIN Read More »
Over the past decades, any attempt at identifying a single, curative treatment for neurodegenerative conditions has failed. For example, over 200 drugs for Alzheimer’s disease (AD) have all but come and gone without any significant contribution to better management of this devastating condition. Clearly this is not for the lack of effort or funding, but
According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, improves motor function, depression, and anxiety behaviors. However, the psychobiotic effects and mechanisms of PS128 in Alzheimer’s disease (AD) remain to be explored. Objectives The goal of the current study was to
The presented data of preclinical studies showed that harmine hydrochloride has antidepressant,antihypoxic, and antiparkinsonian effects, eliminates catalepsy caused by haloperidol in rats, and reducesoligokinesia and rigidity in the parkinsonian syndrome test. In terms of antiparkinsonian effect, harmine hydrochlorideis not inferior to amitriptyline. The study of the relative bioavailability of harmine hydrochloride in experimentalanimals showed that
Alkaloids of Peganum harmala L. and their Pharmacological Activity Read More »