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Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review

Periodontitis, Root Canal /

All the included studies reported higher levels of inflammatory markers, IgG levels of periodontal bacteria, and/or clinical parameters of periodontitis with the two concomitant diseases (some neurodegenerative disease and periodontitis), compared with the diseases isolated (summarized in Figure 2). Despite that we found some minor problems in domains in the qualitative analysis, all the studies have […]

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Temporal trajectory of biofluid markers in Parkinson’s disease

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

At baseline, PD patients showed lower CSF α-syn, Aβ, t-tau and p-tau levels than those of the controls. In all PD patients, CSF α-syn and Aβ decreased in a negative exponential pattern before the onset of motor symptoms, whereas CSF t-tau and p-tau, and serum NfL increased. Patients with cognitive impairment exhibited faster decline of

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Neuroprotective effect of Lactobacillus plantarum DP189 on MPTP-induced Parkinson’s disease model mice

Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The results indicated that L. plantarum DP189 improved behavioral ability and increased the levels of 5-hydroxytryptamine and dopamine of PD mice. L. plantarum DP189 significantly increased the positive rate of tyrosine hydroxylase cells. L. plantarum DP189 activated the ERK2 and AKT/mTOR pathways, promoted the expression of Bcl-2, and inhibited the activities of Bax and Caspase 3. The results indicated that L. plantarum DP189

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Fecal Microbiota Transplantation: A Microbiome Modulation Technique for Alzheimer’s Disease

Fecal Transplants (FMT), Parkinson's Disease /

Microbiota-targeted interventions such as personalized diet, probiotics, or fecal microbiota transplantation (FMT) might represent a potential therapeutic option for AD. This review article discusses the procedure of FMT and its possible side effects on the recipient’s body. In addition, we review the role of FMT in the context of its application in various nervous system-related

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IMPACT OF THE SHORT – CHAIN FATTY ACIDS ON THE MICROBIOTA – GUT – BRAIN AXIS

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

Studies show that short – chain fatty acids have differenteffects by increasing or decreasing the quantity of certain molecules such as GLP-1,peptide YY, insulin, glucagon, ghrelin, leptin and serotonin while they also have animpact on the nervous system. Also is needed to emphasize its role in certainneurological diseases such as Parkinson, autism spectrum disorder and

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Probiotics and the Treatment of Parkinson’s Disease: An Update

Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Probiotic supplementation mediates these pharmacological effects by targeting a variety of cellular and molecular processes, i.e., oxidative stress, inflammatory and anti-inflammatory pathways, as well as apoptosis. Herein, we summarize the effects of probiotics on motor and non-motor symptoms as well as various cellular and molecular pathways in PD. CLICK TO REVIEW

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Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

However, there is limited success in restoring healthy microbial biodiversity in AD and PD patients with general probiotics interventions and fecal microbial therapies. Fortunately, the gut microflora is susceptible to long-term extrinsic influences such as lifestyle and dietary choices, providing opportunities for treatment through comparatively individual-specific control of human behavior. In this review, weexamine the

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Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life

Endotoxin, Lipopolysaccharides (LPS), Root Canal /

CAP-related depression was accompanied by increased levels of NOx, LOOH, AOPP, and TRAP. In CAP participants, there was a strong correlation (r = 0.734, p < 0.001) between root canal LPS and the HDRS score. There were significant and positive associations between CAP or root canal endotoxin with the vegetative and physiosomatic symptoms of the

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Clinical and Pre-Clinical Evidence for Enteric α-Synuclein Involvement in Parkinson’s Disease

A-Synuclein, Gut Dysbiosis, Gut Permeability / Leaky Gut, Vagal Nerve /

While commonly attributed to neuronal death in SNpc, postmortem studies have shown α-syn immunoreactivity and LB pathology inthe peripheral, central, and enteric nervous system (ENS).While the etiology of misfolded α-syn is unknown, variousgut microbiota and substrates are associated with α-syndysfunction. Gastrointestinal (GI) dysfunction, a commonfeature in the prodromal phase of PD patients, and histological evidence

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Food for thought: the emerging role of a ketogenic diet in Alzheimer’s disease management

Diet and Exercise /

Recently, particular attention has been paid to the possible function of three dietary patterns in AD prevention: the Mediterranean diet, the Dietary Approaches to Stop Hypertension (DASH) diet, and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet. These dietary patterns have well-known anti-inflammatory and antioxidant properties, and their neuroprotective properties have been shown to be

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