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Modulation of Neuroinflammation by the Gut Microbiota in Prion and Prion-Like Diseases

Gut Dysbiosis, Gut Microbiota, Mitochondria, Parkinson's Disease, Pre-PD /

One fundamental component of systemic homeostasis is the gut microbiota, which communicates withthe CNS via microbial metabolite production, the peripheral nervous system, and regulation oftryptophan metabolism. Over the past 10–15 years, research focused on the microbiota–gut–brainaxis has culminated in the discovery that dysbiosis, or an imbalance between commensal andpathogenic gut bacteria, can promote CNS pathologies. […]

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The role of oxidative stress and the underlying biological pathways in the pathogenesis of Parkinson’s Disease

Anti-oxidants, Mitochondria /

The mechanisms involved in pathogenesis and progression ofPD is not fully understood but there is overwhelming evidence thatmaintenance of redox potential is important for neuronal survival.Any disruption in the mitochondrial potential disrupts the cellularhomeostasis, which in turn causes more ROS production leadingto neuroinflammation and degeneration. The review attempts toconsolidate key signaling pathways, and proteins that

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Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer’s and Parkinson’s Disease

Gut Microbiota, Mold, Mycotoxins, Olfactory, Parkinson's Disease /

In the case of PD, the fact that the disease is accompanied by other non-motor symptoms in organs highly exposed to the environment (olfactory and gastrointestinal systems) reinforces the hypotheses of the role of environmental factors in the etiology of PD. Many chemicals such as pesticides, metals (iron and lead), polychlorinated biphenyls, solvents such as

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Comparing the Results from Faecal Microbiome Transplantation (Fmt) and Gut Flora Replacement Therapy (Gfrt) using 16s Mrna Microbiome Mappin

Butyrate, Fecal Transplants (FMT), Parkinson's Disease /

We used the data from 10 randomly chosen patients from our cohort of FMT patients and the same for 10 randomly chosenpatients who had received GFRT. We measured their microbiomes using 16S mRNA tests, the results are shown in Tables 3 and 4. The reference values for the laboratory were used for these tests are

Comparing the Results from Faecal Microbiome Transplantation (Fmt) and Gut Flora Replacement Therapy (Gfrt) using 16s Mrna Microbiome Mappin Read More »

Cutaneous Alpha-Synuclein is Correlated with Autonomic Impairment in Isolated REM Sleep Behavior Disorder

A-Synuclein, iRBD, Parkinson's Disease, Pre-PD /

The presence of p-syn at any biopsy site was correlated with both sympathetic (CASS adrenergic r = 0.6, p < 0.05) and total autonomic impairment (CASS total r = 0.6, p < 0.05) on autonomic reflex testing in iRBD patients. These results were independent of the density of p-syn at each site. There was no

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Dietary patterns affect Parkinson’s disease via the microbiota-gut-brain axis

Diet and Exercise, Gut Microbiota, Short Chain Fatty Acids /

The Mediterranean diet reduces the risk of PD with favorable alternations of intestinal microbiota, increases levels of SCFAs, and reduces the TMAO level. Calorie restriction and Fasting-mimicking diet show some neuroprotective effects on PD via increasing β-HB, FGF21, and Ghrelin levels. Meanwhile, both ketogenic and protein-restricted diets show a striking effect on ameliorating motor impairment

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Early constipation predicts faster dementia onset
in Parkinson’s disease

Constipation, Dementia - Lewy Bodies /

Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may bepart of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration,composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessedwith the MDS-UPDRS

Early constipation predicts faster dementia onset
in Parkinson’s disease Read More »

Fecal microbiota transplant as a potential treatment for Parkinson’s disease – A case series

Constipation, Fecal Transplants (FMT) /

In this preliminary uncontrolled case series of 6 PD patients, a treatment with donor FMT infused via colonoscopy, was safe and resulted in improvement of PD motor and non-motor symptoms, including constipation, at 6 months. Further research is needed to assess longer-term maintenance of efficacy and safety, including in large scale randomized controlled trials. CLICK TO

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Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson’s disease

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

In general, the relative proportions of the main bacterial phyla in the microbiotas of PD patients differed from those of healthy subjects, with levels of Firmicutes raised and levels of Bacteroidetes reduced. Dosing with probiotic resulted in a change in bacterial composition in the microbiotas over a 48 h period. Several other indicators of gut health changed upon dosing with

Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson’s disease Read More »

Non-motor symptoms and their use as markers for prodromal and early Parkinson’s Disease

Non-Motor Symptoms, Pre-PD /

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is a disease with a broad spectrum of symptoms, both motor and non-motor, but is often only diagnosed when the motor symptoms begin to appear. By this time however, a large amount of the dopaminergic neurons of the substantia nigra pars compacta have already

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