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Neuronal Autophagy: Characteristic Features and Roles in Neuronal Pathophysiology

Autophagy, Parkinson's Disease /

Autophagy is an important degradative pathway that eliminates misfolded proteins and damaged organelles from cells. Autophagy is crucial for neuronal homeostasis and function. A lack of or deficiency in autophagy leads to the accumulation of protein aggregates, which are associated with several neurodegenerative diseases. Compared with non-neuronal cells, neurons exhibit rapid autophagic flux because damaged […]

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Voice for Health: The Use of Vocal Biomarkers from Research to Clinical Practice

Speech /

Diseases can affect organs such as the heart, lungs, brain, muscles, or vocal folds, which can then alter an individual’s voice. Therefore, voice analysis using artificial intelligence opens new opportunities for healthcare. From using vocal biomarkers for diagnosis, risk prediction, and remote monitoring of various clinical outcomes and symptoms, we offer in this review an

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The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

A-Synuclein, Gut-Brain axis, Parkinson's Disease /

Consequently, the initial α-synuclein pathology inside the CNS is more symmetric, which promotes more symmetric propagation in the brainstem, leading to more symmetric dopaminergic degeneration and less motor asymmetry. At diagnosis, body-first patients already have a larger, more symmetric burden of α-synuclein pathology, which in turn promotes faster disease progression and accelerated cognitive decline. The

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Elucidating the Multi‐Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases

Vitamins / Supplements / Nutraceuticals /

The current review summarizes the popular nutraceuticals showing different effects (anti‐inflammatory, antioxidant, neuro‐protectant, mitochondrial homeostasis, neurogenesis promotion,and autophagy regulation) on vital molecular mechanisms involved in NDs, which can beconsidered as complementary therapy to first‐line treatment. Moreover, owing to its natural source, lower toxicity, therapeutic interventions, biocompatibility, potential nutritional effects, and presence of various anti‐oxidative and

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Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics

Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Thus, BEVs may be both a cause of and solution to neuropathological conditions. In this review, current knowledge of the physiological roles of BEVs as well as state of the art pertaining to the development of therapeutic BEVs in the context of the microbiome-gut-brain axis are summarized. CLICK TO REVIEW

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Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice

Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

As the profound interactions between the gut microbiota and the structure, chemistry, and activity of the brain continue to be discovered, the functional details of how the microbiota-gut-brain-axis works are starting to be resolved. Previous studies have suggested B. longum can cause changes in brain chemistry and activity [20]. Other research has revealed that modifications to expression of

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Probiotic Properties and Immunomodulatory Activity of Lactobacillus Strains Isolated from Dairy Products

Probiotics, Prebiotics and Symbiotics /

Studies of the gut microbiota on health and disease are of high importance, and the role of probiotics and prebiotics as modulators of the microbiota require studies to find the best candidates. The obtained results show that the Lactobacillus strains evaluated possess properties such as adherence to cultured cells, inhibition of the colonization and growth

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Association of small intestinal bacterial overgrowth with Parkinson’s disease: a systematic review and meta-analysis

Gut Dysbiosis, Parkinson's Disease, Pre-PD /

Our meta-analysis identified a strong association between SIBO and PD with approximately half of PD patients testing positive for SIBO. These relationships were significantly different according to type of diagnostic test and geographic area. Therefore, we must pay close attention to enteric microorganisms to prevent nervous system diseases. CLICK TO REVIEW

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The role of gut dysbiosis in Parkinson’s disease: mechanistic insights andtherapeutic options

A-Synuclein, Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

We highlight recent discoveries and alterations of the gut microbiota in Parkinson’s disease, and highlight current mechanistic insights on the microbiota-gut-brain axis in disease pathophysiology. We discuss the interactions between production and transmission of α-synuclein and gut inflammation and neuroinflammation. In addition, we also draw attention to diet modification, use of probiotics and prebiotics and

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