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Dual Roles of Microglia in the Basal Ganglia in Parkinson’s Disease

A-Synuclein /

The activated microglia then eliminate the hyperactive glutamatergic synapses. Synapse elimination may be the mechanism underlying the compensation that masks the appearance of PD symptoms despite substantial DAergic neuronal loss. Microglial senescence may correlate with their enhanced neurotoxicity in the SNc and the reduced compensatory actions in the basal ganglia outputs. The dual roles of […]

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Gut-brain axis and immunoneuroendocrine modulation in neurological and psychiatric disorders: Asystematic review

Short Chain Fatty Acids /

Communication between the GI tract and the CNS occurs via the neuronal,endocrine, and immunological pathways through a) the production of neurotransmitters, b) the tryptophan metabolism, c) the modulation of the immunological activity in the CNS and the SNE, d) production of short chain fatty acids, e) the production of intestinal hormones, and f) the production

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Natural polyphenols in central nervous system disorders

Parkinson's Disease, Polyphenols, Vitamins / Supplements / Nutraceuticals /

Reduced oxidative stress causes the suppression of the risk of associated neurodegenerative diseases, such as, Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), Parkinson’s disease (PD) and Huntington’s disease (HD). Consequently, the analysis indicates that polyphenol beneficial effects on human brain activity and this review describe these implications by discussing the latest mechanistic hypothesis. CLICK TO

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Biochemical Markers in the Urine Associated with Gastrointestinal Mold-Overgrowth Are Linked with Elevated Urinary Mycotoxins in Patients with Suspected Mold Illness

Mold, Mycotoxins /

Exposure to mycotoxins can lead to acute as well as chronic toxic effects, which are dependent on the mycotoxin type, the amount, length of the exposure, and the health, age, and sex of the patient. Dietary deficiency, co-existing health conditions, and environmental/chemical exposure potentially create a compounding effect which can impact the severity of symptoms.

Biochemical Markers in the Urine Associated with Gastrointestinal Mold-Overgrowth Are Linked with Elevated Urinary Mycotoxins in Patients with Suspected Mold Illness Read More »

Alpha-synuclein induces progressive changes in brain microstructure and sensory-evoked brain function that precedes locomotor decline.

A-Synuclein, ENS /

At 12 weeks post-injection, a separate 43 and distinct pattern of structural and sensory-evoked functional brain activity changes was 44 observed that are co-localized with previously reported regions of α-syn pathology and immune 45 activation. Microstructural changes in the pons at 12 weeks post-injection were found to predict 46 survival time and preceded measurable locomotor

Alpha-synuclein induces progressive changes in brain microstructure and sensory-evoked brain function that precedes locomotor decline. Read More »

Functional imaging of the brainstem during visually-guided motor control reveals visuomotor regions in the pons and midbrain

A-Synuclein, ENS /

Visuomotor activity during visually-guided pinch-grip force was measured while controlling for force without visual feedback activity and visual stimuli without force activity in healthy adults. Using physiological noise correction and multiple task repetitions, we demonstrated that visuomotor activity occurs in the inferior portion of the basilar pons and the midbrain. These findings provide direct evidence

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Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics

Parkinson's Disease, Therapies /

In this rapidly evolving era of precision medicine, understanding mechanisms underlying the beneficial versus detrimental impact of the Val66Metpolymorphism, and/or its interaction with aging, will aid in the development of safe and optimized therapeutic approaches for remodeling the parkinsonian striatum. CLICK TO REVIEW

Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics Read More »

Metals associated neurodegeneration in Parkinson’s disease: Insight to physiological, pathological mechanisms and management

A-Synuclein, Dementia - Lewy Bodies, Iron, Parkinson's Disease, Pre-PD /

 There is increasing evidence that heavy metals normally present in the human body in minute concentration also cause accumulation to initiate the free radical formation and affecting the basal ganglia signaling. In this review, we explored how these metals affect brain physiology and their roles in the accumulation of toxic proteins (α-synuclein and Lewy bodies).

Metals associated neurodegeneration in Parkinson’s disease: Insight to physiological, pathological mechanisms and management Read More »

Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

Butyrate, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

This review provides an overview of the current knowledge of these effects, with specific focus on energy metabolism, intestinal barrier, immune system, and disease activity in IBD. To conclude, more research is needed on the cross-feeding mechanisms in the gut microbiome, as well as on the therapeutic potential of SCFAs on different disease models. Also

Short chain fatty acids and its producing organisms: An overlooked therapy for IBD? Read More »