Rob

Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models

Anti-oxidants, Parkinson's Disease, Pre-PD /

Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from […]

Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models Read More »

Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease

Constipation, Probiotics, Prebiotics and Symbiotics /

This study showed that consumption of a multi-strain probiotic (Hexbio®) over 8 weeks improved bowel opening frequency and whole gut transit time in PD patients with constipation. CLICK TO REVIEW

Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease Read More »

Unravelling the potential of gut microbiota in sustaining brain health and their current prospective towards development of neurotherapeutics

Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Therapies /

Reports also showed that colonization of gut microbiota isolated from patients suffering from neurodegenerative disease leads to the development of enhance pathological outcomes in animal models. Hence, a systematic understanding of the dominant role of specific gut microbiome towards development of different neurodegenerative diseases could possibly provide novel insight into the use of probiotics and

Unravelling the potential of gut microbiota in sustaining brain health and their current prospective towards development of neurotherapeutics Read More »

Investigating the Putative Mechanisms Mediating the Beneficial Effects of Exercise on the Brain and Cognitive Functions

Diet and Exercise, Parkinson's Disease, Pre-PD /

A variety of brain disorders including alzheimer’s disease, parkinson’s disease, chronic stress, age-related cognitive decline, psychological disorders have been revealed to avoid, restore, or improve by different procedures of physical exercise. CLICK TO REVIEW

Investigating the Putative Mechanisms Mediating the Beneficial Effects of Exercise on the Brain and Cognitive Functions Read More »

Alpha-synuclein preformed fibrils: a tool to understand Parkinson’s disease and develop disease modifying therapy

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by multiple motor and non-motor symptoms, which include, among others, constipation, sleep disturbance, bradykinesia, gait and balance abnormalities, muscle stiffness and resting tremor. The motor symptoms are caused by progressive age-related death of dopaminergic neurons and in the vast majority of patients suffering from

Alpha-synuclein preformed fibrils: a tool to understand Parkinson’s disease and develop disease modifying therapy Read More »

microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson’s disease as noninvasive biomarkers

iRBD, Pre-PD /

The damage may start at an early period of brain degeneration, in the non-motor or “prodromal” stage, where autonomic, mood and sleep changes are often manifested. REM-sleep behavior disorder (RBD) is the prodromal manifestation with the highest odds for conversion into PD, thereby a valuable phenotype for disease prediction. The present review focuses on microRNAs’

microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson’s disease as noninvasive biomarkers Read More »

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

A-Synuclein, Gut-Brain axis /

. This study does not support the hypothesis of a transmission of a-synuclein pathology through the vagus nerve and the dorsal motor nucleus of the vagus. Instead, our results suggest a possible systemic mechanism in which the general circulation would act as a route for long-distance bidirectional transmission of endogenous a-synuclein between the enteric and

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates Read More »

Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease

A-Synuclein, Fecal Transplants (FMT), Iron, Pre-PD /

We argue that there is significant evidence that bacterial inflammagens fuel this systemic inflammation, and might be central to thedevelopment of PD. We also discuss the processes whereby bacterial inflammagens may be involved in causing nucleation of proteins, including of α-Syn. Lastly, we review evidence that iron chelation, pre-and probiotics, as well as antibiotics and

Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease Read More »

Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress‐induced depressive‐like behavior

Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

The gut‐microbiota‐brain axis is the most important complex and bidirectional pathway between the gastrointestinal tract and the central nervous system. This study investigated the potential of microbe‐induced gut‐to‐brain signaling to modulate the effect of stress on depressive‐like behavior, intestinal barrier, and neuroinflammation. Result showed that fecal microbiota transplantation increased the consumption of sucrose solutions and

Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress‐induced depressive‐like behavior Read More »