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Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modulation of intestinal tight junctions and gut microbiota and inhibition of inflammation

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Vitamins / Supplements / Nutraceuticals /

WSBCW upregulated intestinal junction proteins, increased the abundance of Bifidobacterium genus, Desulfovibrio genus and inhibited Bacteroides fragillis group in the gut microbiota, increased intestinal villi lengths, and decreased blood levels of inflammatory cytokines. Our study provided preclinical evidence to verify the effectiveness of WSBCW in gastrointestinal health and elucidate mechanistic insights. The results warrant further investigations to evaluate the […]

Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modulation of intestinal tight junctions and gut microbiota and inhibition of inflammation Read More »

Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease

A-Synuclein, Biomarkers, Pre-PD /

In human post-mortem liver tissue, we identifed cases with neuropathologically confrmed α-syn pathology containing α-syn within hepatocellular structures to a higher degree (75%) than control subjects without α-syn accumulation in the brain (57%). Our results reveal that α-syn accumulates within the liver and may be derived from the brain or other peripheral sources. Collectively, our

Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease Read More »

Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Pre-PD, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

In conclusion, niacin attenuated the weight loss and diarrhea, and improved the expression of antimicrobial peptides, and enhanced intestinal epithelial barrier function, and improved the microbiota in the colonic contents of weaned piglets, suggesting that niacin may be an effective way for weaned piglets to maintain the gut and overall health. CLICK TO REVIEW

Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation Read More »

Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men

Fasting, Iron /

Eight days of total starvation diet affected the body composition and decreased exercise capacity. Further, fasting decreased the expression of genes associated with iron storage and export, and increased the expression of genes involved in iron acquisition. Conversely, only PCBP2 protein increased after fasting; however, an upward trend was apparent for all proteins. In conclusion,

Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men Read More »

Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease

Iron, Parkinson's Disease, Pre-PD /

The highest cellular iron levels in neurons were located in the cytoplasm, which might increase the source of non-chelated Fe3+, implicating a critical increase in the labile iron pool. Indeed, neuromelanin is characterized by a significantly higher loading of iron including most probable the occupancy of low-affinity iron binding sites. Quantitative trace element analysis is

Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease Read More »

The cell biology of Parkinson’s disease

A-Synuclein, Parkinson's Disease /

Parkinson’s disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD biology has been enriched by the identification of genes involved in its rare, inheritable forms, termed PARK genes. These genes encode proteins including α-syn, LRRK2, VPS35, parkin, PINK1, and DJ1, which can

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Biomarkers and the Role of α-Synuclein in Parkinson’s Disease

A-Synuclein, Biomarkers, Pre-PD /

This review article aims to summarize useful biomarkers for the diagnosis of PD, as well as the biomarkers used to monitor disease progression. This review article describes the role of α-Syn in PD and how it could potentially be used as a biomarker for PD. Also, preclinical and clinical investigations encompassing genetics, immunology, fluid and

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Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Pre-PD /

These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation, inflammation restriction as well as epithelial barrier maintenance, thus finally determine the fate of UC progression and give implications for functional food development for prevention and

Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis Read More »

Dietary restrictions modulate the gut microbiota: Implications for health and disease

Biomarkers, Butyrate, Diet and Exercise, Gut Permeability / Leaky Gut, Gut-Brain axis /

The data suggests that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression of several diseases such as obesity, diabetes, neurological diseases or inflammatory bowel disease. Finally, the relevance of the findings for clinical practice is evaluated and approaches for future research are proposed. CLICK TO REVIEW

Dietary restrictions modulate the gut microbiota: Implications for health and disease Read More »

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila

A-Synuclein, Biomarkers, Pre-PD /

Taken together, our results presented here indicate α-syn accumulation in presynaptic terminals affects synaptic proteins and active zone integrity that impair neuronal function. The resultant synaptopathy causes behavioural deficits and progressive age-related neurodegeneration. Thissuccession of phenotypes recapitulates key events of dying-back like neurodegeneration5,27,92 and provide insights into the pathogenic mechanisms underlying synaptopathy, the likely initiating

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila Read More »