Large biomarker development programs are undertaken to identify disease signatures that will improve patient selection and outcome measures in clinical trials. In this review, we summarize PD-related mechanisms that can serve as targets of therapeutic interventions aiming to slow or modify disease progression, as well as previous and ongoing clinical trials in each field, and […]
Novel targeted therapies for Parkinson’s disease Read More »
We study the effects of these interventions on the human gut microbiome by testing shifts in microbial diversity, changes in individual microbial abundances, and microbial network wiring between groups of matched subjects via randomization-based inference. In the smoking prevention scenario, we identify a small interconnected group of taxa worth further scrutiny, including Christensenellaceae and Ruminococcaceae
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatographymass spectrometry (LC-MS) to analyse 274 samples
Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease Read More »
Previous studies have reported that gut microbiota, permeability, short-chain fatty acids (SCFAs), and inflammation are altered in Parkinson’s disease (PD), but how these factors are linked and how they contribute to disease processes and symptoms remains uncertain. This study sought to compare and identify associations among these factors in PD patients and controls to elucidate
We found abnormal ECN and normal DMN as a possible hallmark of cognitive dysfunctions in early α-synucleinopathies. We replicated abnormalities in BGN and SMN corresponding to subclinical movement disorder of RBD. RsfcMRI may provide an early biomarker of both cognitive and motor network dysfunctions of α-synucleinopathies. CLICK TO REVIEW
Prefrontal network dysfunctions in rapid eye movement sleep behavior disorder Read More »
Molecular hydrogen is the smallest molecule in the world, but don’t let its size fool you, molecular hydrogen or H2 can be noted as one of the most potent antioxidants available to us. Being the very first element, hydrogen has been a part of evolution from the origins of the universe. The use of molecular
Hydrogen for your Health? The Many Benefits of Molecular Hydrogen Read More »
Connectivity between the insula and precuneus may be associated with cognitive function among patients with isolated rapid eye movement sleep behavior disorder (iRBD), according to the results of a cross-sectional study published in Sleep Medicine. Study researchers recruited patients (n=50) diagnosed by video-polysomnography with iRBD at Seoul National University Hospital Sleep Clinic and healthy controls (n=20)
Predictive biomarkers of Parkinson’s Disease progression are needed to expedite neuroprotective treatment development and facilitate prognoses for patients. This work uses measures derived from resting-state functional magnetic resonance imaging, including regional homogeneity (ReHo) and fractional amplitude of low frequency fluctuations (fALFF), to predict an individual’s current and future severity over up to 4 years and to elucidate
The proposed method achieved average classification accuracies of up to 92 % in vowels, and 97 % in words. There is an improvement in accuracy ranging from 10% to 40 % compared to existing methods. Further, the developed models are evaluated upon an independent dataset. Results on this separate test set show accuracies ranging from
We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as