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Iron homeostasis in host and gut bacteria – a complex interrelationship

Gut Microbiota, Iron /

Iron deficiency is the most frequent nutritional deficiency in the world with an estimated 1.4 billion people affected. The usual way to fight iron deficiency is iron fortification, but this approach is not always effective and can have undesirable side effects including an increase in the growth and virulence of gut bacterial pathogens responsible for […]

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Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins

A-Synuclein, ENS, Vagal Nerve /

In this work, we investigated the ability of amyloid fibrils derived from two food proteins to heterologously seed the aggregation of the PD-related aSyn protein. While β-lactoglobulin amyloid fibril seeds were not able to induce aSyn aggregation, we identified a fibril surface–mediated nucleation mechanism for the seeding of aSyn aggregation by hen egg white lysozyme

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The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson’s disease

A-Synuclein /

 Interestingly, we found that TCE not only induced LRRK2 kinase activity in the brain, but produced a significant dopaminergic lesion in the nigrostriatal tract, elevated oxidative stress, and caused endolysosomal dysfunction and α-synuclein accumulation. Together, these data suggest that TCE-induced LRRK2 kinase activity contributed to the selective toxicity of dopaminergic neurons. We conclude that gene-environment interactions

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Parkinson’s Disease: Possible Mechanisms for Nutritional Approaches

Diet and Exercise, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is among the most common chronic neurodegenerative conditions, affecting 1% of those over 60 years of age, and involves motor and non-motor impairments. Alterations in normal physiology may become apparent years – in some cases, 10–20 years – before established diagnostic criteria are met. Thus, better clinical outcomes may result when practitioners

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Excessive Muscle Activity Increases Over Time in Idiopathic REM Sleep Behavior Disorder

iRBD /

Excessive tonic and phasic EMG activity during REM sleep increases over time in subjects with idiopathic RBD. This finding suggests that, in subjects with idiopathic RBD, there is an underlying progressive pathologic process damaging the brainstem structures that modulate REM sleep. CLICK TO REVIEW

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Objective sleep data as predictors of cognitive decline in dementia with Lewy Bodies and Parkinson’s disease

Dementia - Lewy Bodies, iRBD, Pre-PD /

Our data suggests that PSG data can be useful in predicting cognitive decline in PD but not in DLB patients. In PD patients, an RBD diagnosis is predictive of cognitive deterioration, confirming the notion that this non-motor symptom relates to a malignant sub-type. Tonic excessive muscular activity, but not other RBD features, had predictive value in

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Boxing with Parkinson’s Disease: findings from a qualitative study using self-determination theory

Diet and Exercise, Parkinson's Disease, Pre-PD /

Adults with Parkinson’s disease (PD) experience debilitating symptoms that may be mitigated by boxing. Yet, attrition from boxing programs is problematic. Understanding whether PD-specific boxing programs can enhance motivation to remain physically active is important. This study investigated adults’ experiences within a PD-specific boxing program and explored their perspectives on how the program has influenced

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A Review on the Health Effects of Pesticides Based on Host Gut Microbiome and Metabolomics

Butyrate, Gut Microbiota, Pesticides, Short Chain Fatty Acids /

A comprehensive analysis of the changes in the gut microbiota and metabolic profile of host will help in understanding the internal mechanism of pesticide-induced toxic effects. This study reviewed the composition and function of the gut microbiota of host, as well as the analysis methods and applications of metabolomics. Importantly, the latest research on the

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The Role of Salivary Biomarkers in the Early Diagnosis of Alzheimer’s Disease and Parkinson’s Disease

A-Synuclein, Biomarkers, iRBD, Pre-PD /

This review aims to provide an insight into the current literature concerning salivary biomarkers used in the diagnosis of AD and PD. The most commonly studied salivary biomarkers in AD are β-amyloid1-42/1-40 and TAU protein, as well as α-synuclein and protein deglycase (DJ-1) in PD. Studies continue to be conducted on this subject and researchers

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