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Subtle oromotor signs in early Parkinson’s disease before clinical manifestations of dysphagia

oropharyngeal, Symptoms / Diagnosis /

Multiple lingual-waves, reverse-tongue thrust, with delayed velar control attributed to incoordinated muscular rhythm. Variable oropharyngeal transit time (0.64 to 2.25 msec) in PD ascribed to brainstem degenerative changes. Findings imply that subtle observable early oromotor signs as pre-clinical manifestation when evaluated with non-invasive, non-contrast dynamic MRI support early intervention, to prevent late-stage aspiration episodes and […]

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Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota

Gut Dysbiosis, Gut Microbiota, Therapies /

The L-dopa produced by the intestinal bacteria enters the brain through the circulation and is transformed to dopamine. To verify the gut–brain dialog activated by BBR’s effect, Enterococcus faecalis or Enterococcus faecium was transplanted into Parkinson’s disease (PD) mice. The bacteria significantly increased brain dopamine and ameliorated PD manifestation in mice; additionally, combination of BBR with bacteria showed better therapeutic

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Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Diet and Exercise, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Probiotics, Prebiotics and Symbiotics /

Gut dysbiosis can affect brain immune homeostasis through the microbiota–gut–brain axis and can play a key role in the pathogenesis of neurodegenerative diseases, including dementia and Alzheimer’s disease (AD). The relationship between gut dysbiosis and AD is still elusive, but emerging evidence suggests that it can enhance the secretion of lipopolysaccharides and amyloids that may

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Gastrointestinal biopsies and amyotrophic lateral sclerosis – results from a cohort study of 1.1 million individuals

Gut Dysbiosis, Gut Microbiota /

Individuals with a GI biopsy result of normal mucosa—representing potentially a distinct type of GI dysfunction—had a higher future risk of ALS. No association was however noted for a GI biopsy result of non-specific inflammation. Further studies are needed to validate this finding and to understand the underlying reasons for the contrasting result pattern. CLICK

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The Efficacy of Ketogenic Therapies in the Clinical Management of People with Neurodegenerative Disease

Diet and Exercise /

Based on available evidence, exogenous ketogenic agents may be more feasible than dietary interventions in NDD from a compliance and adherence perspective; more research is required to confirm this. Recommendations for future research include improving exogenous formulations to reduce adverse effects, exploring interindividual factors affecting response-to-treatment, and establishing a “minimum required dose” for clinically meaningful

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Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis

Butyrate, Gut Microbiota, Metabolites, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Hydroxycarboxylic acid receptor 2 (HCA2) is vital for sensing intermediates of metabolism, including β-hydroxybutyrate and butyrate. It also regulates profound anti-inflammatory effects in various tissues, indicating that HCA2 may serve as an essential therapeutic target for mediating inflammation-associated diseases. Butyrate and niacin, endogenous and exogenous ligands of HCA2, have been reported to play an essential role

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Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome– a pilot study

Anti-oxidants, Butyrate, Gut Microbiota, Metabolites, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

The modulatory effect of vitamins on the gut microbiome and related host health benefits remain largely unclear. We investigated the effects of colon-delivered vitamins A, B2, C, D, and E on the gut microbiota using a human clinical study and batch fermentation experiments, in combination with cell models for the assessment of barrier and immune

Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome– a pilot study Read More »

The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols

Anti-oxidants, Gut Microbiota, Polyphenols, Probiotics, Prebiotics and Symbiotics /

Thereby,after selecting, analyzing and debating the main articles on this topic, the bacteria related to the pathogenesis of ALS have been identified, among which we can positively highlight the presence mainly of Akkermansia muciniphila, but also Lactobacillus spp., Bifidobacterium spp. or Butyrivibrio fibrisolvens. Nevertheless, the presence of Escherichia coli or Ruminococcus torques stand out negatively

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Prophylactic Role of Aloe Components, Butyrate Fermented, Micrnas, and Hyaluronan on Alzheimer’s Disease, Parkinson’s Disease, and Osteoarthritis in Knee Joints

Butyrate, Gut Dysbiosis, Gut-Brain axis, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Host microbial cross talk is essential to maintain intestinal homeostasis. However, maladaptation of the response through microbial dysbiosis or defective host defense toward invasive intestinal microbial results in chronic inflammation and the mild cognitive impairment. The role of active constituents from Aloe species, fermented butyrate, and micRNAs on Alzheimer’s disease, and Parkinson’s disease is discussed

Prophylactic Role of Aloe Components, Butyrate Fermented, Micrnas, and Hyaluronan on Alzheimer’s Disease, Parkinson’s Disease, and Osteoarthritis in Knee Joints Read More »