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Abnormal Gray Matter Volume and Functional Connectivity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder

iRBD, Pre-PD /

Higher GMV in the cerebellum may be linked with the abnormal motor behaviors during REM sleep in patients with PD-RBD, and lower GMV and FC in the posterior regions may indicate that PD-RBD correspond to more serious neurodegeneration, especially the visuospatial–executive function impairment and delayed memory impairment. These findings provided new insights to learn more […]

Abnormal Gray Matter Volume and Functional Connectivity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder Read More »

Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials

Anti-oxidants, Diet and Exercise, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Author links open overlay panelIn vitro and in vivo studies have associated astaxanthin’s unique molecular features with several health benefits, including neuroprotective, cardioprotective and antitumoral properties, suggesting its therapeutic potential for the prevention or co-treatment of dementia, Alzheimer, Parkinson, cardiovascular diseases and cancer. Benefits on skin and eye health promotion have also been reported, highlighting its

Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials Read More »

Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury

Fecal Transplants (FMT), Gut Dysbiosis /

In conclusion, the current study showed that TBI can induce the gut microbiome dysbiosis and that FMT can rescue gut microbiota dysbiosis, relieve the neurological deficits, and exert an antioxidation effect through decreasing TBI-induced TMAO and increasing the antioxidant enzyme MsrA expression in the hippocampus. CLICK TO REVIEW

Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury Read More »

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models

A-Synuclein, Pre-PD /

Tat-βsyndegron decreased α-synuclein aggregates and microglial activation in an α-synuclein preformed fibril model of spreading synucleinopathy in transgenic mice overexpressing human A53T α-synuclein. Moreover, Tat-βsyn-degron reduced α-synuclein levels and significantly decreased the parkinsonian toxin-induced neuronal damage and motor impairment in a mouse toxicity model of PD. These results show the promising efficacy of Tat-βsyn-degron in

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models Read More »

Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson’s disease

Gut-Brain axis, Pre-PD, Probiotics, Prebiotics and Symbiotics /

PS128 administration also attenuated MPTP-induced oxidative stress and neuroinflammation in the nigrostriatal pathway. Fecal analysis showed that PS128 modulated the gut microbiota. L. plantarum abundance was significantly increased along with methionine biosynthesis-related microbial modules. PS128 also suppressed the increased family Enterobacteriaceae and lipopolysaccharide and peptidoglycan biosynthesis-related microbial modules caused by MPTP. In conclude, PS128 ingestion alleviated MPTP-induced motor deficits and

Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson’s disease Read More »

Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut–Brain Axis

Constipation, Gut-Brain axis, Pre-PD, Probiotics, Prebiotics and Symbiotics, Vagal Nerve /

The hypothalamic–pituitary–adrenal axis was modulated by PS128 with decreased corticosterone concentration in serum and the expression of mineralocorticoid receptors in the amygdala. Oral administration of PS128 inhibited 5-HTPinduced VH during CRD. The ameliorative effect on VH suggests the potential application of PS128 for IBS. CLICK TO REVIEW

Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut–Brain Axis Read More »

Associations between probable REM sleep behavior disorder, olfactory disturbance, and clinical symptoms in Parkinson’s disease: A multicenter cross-sectional study

iRBD, Olfactory, Pre-PD /

About 33% of the patients with PD had pRBD based on the questionnaires, and both motor and non-motor functions were significantly decreased in these patients. These results suggest that more extensive degeneration occurred in patients with non-demented PD with RBD. CLICK TO REVIEW

Associations between probable REM sleep behavior disorder, olfactory disturbance, and clinical symptoms in Parkinson’s disease: A multicenter cross-sectional study Read More »

Short-chain fatty acids in the context of Parkinson’s disease

A-Synuclein, Butyrate, Short Chain Fatty Acids /

Taken together, there is strong evidence that the gastrointestinal microbiome is altered in PD and this is similarly true for the composition of the intestinal metabolome. SCFAs are increasingly studied intestinal metabolites that have shown great potential to influence disease processes in neuroinflammatory disorders. Their role for neurodegenerative movement disorders such as PD is still

Short-chain fatty acids in the context of Parkinson’s disease Read More »

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

A-Synuclein, Biomarkers, Dementia - Lewy Bodies, iRBD, Pre-PD /

In patients with IRBD, RT-QuIC detects misfolded α-synuclein in the CSF with both sensitivity and specificity of 90%, and α-synuclein positivity was associated with increased risk of subsequent diagnosis of Parkinson’s disease or dementia with Lewy bodies. Detection of α-synuclein in the CSF represents a potential prodromal marker of Parkinson’s disease and dementia with Lewy bodies. If

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study Read More »