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Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Anti-oxidants, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may […]

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Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson’s disease

A-Synuclein, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a multifocal degenerative disorder for which there is no cure. The majority of cases are sporadic with unknown etiology. Recent data indicate that untreated patients with de novo PD have increased colonic permeability and that both de novo and premotor patients have pathological expression of α-synuclein (α-syn) in their colon. Both

Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson’s disease Read More »

The Gut Microbiota Influenced by the Intake of Probiotics and
Functional Foods with Prebiotics Can Sustain Wellness and
Alleviate Certain Ailments like Gut-Inflammation and
Colon-Cancer

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Permeability / Leaky Gut, Probiotics, Prebiotics and Symbiotics /

The gut microbiota is composed of several microbial strains, with diverse and variablecombinations in healthy and sick persons, changing at different stages of life. A healthy balancebetween host and gut microorganisms must be maintained in order to perform the normal physiological, metabolic, and immune functions and prevent disease development. Disturbances in the balanceof the gut

The Gut Microbiota Influenced by the Intake of Probiotics and
Functional Foods with Prebiotics Can Sustain Wellness and
Alleviate Certain Ailments like Gut-Inflammation and
Colon-Cancer Read More »

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management

Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD /

The identification of Parkinson’s disease (PD) is mainly dependent on motorsymptoms, while the non-motor symptoms exist even decades ahead of the PDdiagnosis. According to Braak’s hypothesis, the enteric plexus is the first affectedsite during the pathological development of PD, and gastrointestinal (GI) symptomsappear during the onset of the disease. Although GI symptoms decrease the lifequality

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management Read More »

The Role of Gut Microbiome and Dysbiosis in Common Psychological,
Neurological, and Behavioral Disorders

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

According to psychobiotic research expansion, the gut microbiome—a colony of more than 1000 species—is connected to brainhealth and state of mind. Historically, even though a variety of body parts and systems were linked to the nervous system in thenineteenth century, researchers began began researching the gut, especially the stomach, calling it ‘the great abdominal brain’,

The Role of Gut Microbiome and Dysbiosis in Common Psychological,
Neurological, and Behavioral Disorders Read More »

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management

A-Synuclein, Gut Dysbiosis, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The identification of Parkinson’s disease (PD) is mainly dependent on motorsymptoms, while the non-motor symptoms exist even decades ahead of the PDdiagnosis. According to Braak’s hypothesis, the enteric plexus is the first affectedsite during the pathological development of PD, and gastrointestinal (GI) symptomsappear during the onset of the disease. Although GI symptoms decrease the lifequality

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management Read More »

THE MICROBIOTA-GUT-BRAIN AXIS

A-Synuclein, Butyrate, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However,the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms withinand on our bodies) as one of the key regulators of gut-brain function and has led to the appreciationof the importance of a distinct microbiota-gut-brain axis.This axis

THE MICROBIOTA-GUT-BRAIN AXIS Read More »

Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may

Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases Read More »

Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

Ayahuasca, Gut Microbiota /

There has been a renewed interest in the potential use of psychedelics for the treatment of psychiatric conditions. Nevertheless, little is known about the mechanism of action and molecular pathways influenced by ayahuasca use in humans. Therefore, for the first time, our study aims to investigate the human metabolomics signature after consumption of a psychedelic, ayahuasca, and its connection

Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience Read More »