Rob

Dietary manipulation of the gut microbiome in inflammatory bowel disease
patients: Pilot study

Diet and Exercise, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinalmicrobiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linkedto inflammation. Here, we aim to define the impact of specific foods on bacterial species commonlydepleted in patients with IBD to better inform dietary treatment. We performed a single-arm, prepost […]

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patients: Pilot study Read More »

Alpha-Synuclein-Specific Naturally Occurring Antibodies
Inhibit Aggregation In Vitro and In Vivo

A-Synuclein, Parkinson's Disease /

Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of theinnate immune system, produced without prior contact to their specific antigen, and polyreactive.The abundance of nAbs against αSyn is altered in patients with PD. In this work, we biophysicallycharacterized nAbs against

Alpha-Synuclein-Specific Naturally Occurring Antibodies
Inhibit Aggregation In Vitro and In Vivo Read More »

Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson’s Disease Pathophysiology

A-Synuclein, Parkinson's Disease, Pesticides /

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the cardinal features of tremor, bradykinesia, rigidity, and postural instability, in addition to other non-motor symptoms. Pathologically, PD is attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta, with the hallmark of the presence of intracellular protein aggregates of α-synuclein in

Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson’s Disease Pathophysiology Read More »

Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis

A-Synuclein, Butyrate, Parkinson's Disease, Short Chain Fatty Acids /

Neurodegenerative protein conformational diseases are characterized by misfolding and aggregation of metastable proteins encoded within the host genome. The host is also home to thousands of proteins encoded within exogenous genomes harbored by bacteria, fungi, and viruses. Yet, their contributions to host protein-folding homeostasis, or proteostasis, remain elusive. Recent studies, including our previous work, suggest

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Psychobiotics in Health, Longevity, and Neurological Disorders

Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

Psychobiotics are an emerging class of probiotics that, when ingested in ample amounts, confer mental health benefits through interacting with gastrointestinal (GI) microbiota in patients with psychiatric problems. These mind-altering groups of probiotics modulate the functions and behavior of the central nervous system via the gut–brain axis to improve GI health and exert anxiolytic and

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Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice

Butyrate, Gut Microbiota, Parkinson's Disease, Short Chain Fatty Acids /

Short-chain fatty acids (SCFAs) produced by the gut microbiota have previously been demonstrated to play a role in numerous chronic inflammatory diseases and to be key mediators in the gut-bone signaling axis. However, the role of SCFAs in bone fracture healing and its impact on systemic inflammation during the regeneration process has not been extensively

Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice Read More »

Alpha-synuclein as a Potential Biomarker for Parkinson’s Disease and Other
Synucleinopathies: Gaps, Challenges, and Opportunities

A-Synuclein, Biomarkers /

Parkinson’s disease (PD), the second most common progressive neurodegenerative disease,develops and progresses for 10-15 years before the clinical diagnostic symptoms of thedisease are manifested. Furthermore, several aspects of PD pathology overlap with otherneurodegenerative diseases (NDDs) linked to alpha-synuclein aggregation, also calledsynucleinopathies. Therefore, there is an urgent need to discover and validate earlydiagnostic and prognostic markersthat

Alpha-synuclein as a Potential Biomarker for Parkinson’s Disease and Other
Synucleinopathies: Gaps, Challenges, and Opportunities Read More »

Periodontal inflammatory disease is associated with the risk of Parkinson’s disease: a population-based retrospective matched-cohort study

endondonics, Oral Microbiome, Parkinson's Disease /

Individuals exposed to PID were 1.431 times more likely to develop PD than those who were not exposed. However, future long-term, larger or national data sets combined with genes, environmental exposure, lifestyle changes, dietary habits, and accurately defined PD diagnosis should be investigated to support the current research results. CLICK TO REVIEW

Periodontal inflammatory disease is associated with the risk of Parkinson’s disease: a population-based retrospective matched-cohort study Read More »

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

A-Synuclein, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The cellular hallmarks of Parkinson’s disease (PD) are the loss of nigral dopaminergic neurons and the formation of α-synuclein-enriched Lewy bodies and Lewy neurites in the remaining neurons. Based on the topographic distribution of Lewy bodies established after autopsy of brains from PD patients, Braak and coworkers hypothesized that Lewy pathology primes in the enteric

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats Read More »

Hydrogen Sulfide Produced by Gut Bacteria May Induce Parkinson’s Disease

A-Synuclein, Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

Several bacterial species can generate hydrogen sulfide (H2S). Study evidence favors the view that the microbiome of the colon harbors increased amounts of H2S producing bacteria in Parkinson’s disease. Additionally, H2S can easily penetrate cell membranes and enter the cell interior. In the cells, excessive amounts of H2S can potentially release cytochrome c protein from

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