Brain-derived neurotrophic factor (BDNF) is a protein that performs a neurotrophic function.
BDNF and its receptors are widely expressed in the nervous system and can promote the growth
of neurons and the formation of neuronal synapses in the brain. Studies have shown that a lack of
BDNF can lead to impairment of memory and cognitive functions, indicating that BDNF plays an
important role in mental illness and neurodegenerative diseases. The combination of stem cells
and BDNF-releasing nanomaterials holds great promise in regenerative medicine, especially in
the treatment of neurological diseases. For example, Alzheimer’s disease, depression, Parkinson’s
disease, spinal cord injury, etc. The combination of stem cell/pharmacologically active carrier
and BDNF-nano/hydrogel provided a useful new type of local delivery tool for the treatment of
the nervous system and other diseases. It can not only provide BDNF but also stem cells. These
studies will provide a scientific basis for the development and application of BDNF in the future. CLICK TO REVIEW
Keywords: Brain-derived neurotrophic factor; Pathogenesis; Nanomaterials; Hydrogel; Drug
delivery; Neuropsychiatric diseases.