Brain-derived neurotrophic factor, or BDNF, is a growth factor with broad relevance for aging, brain function, behavior, metabolism, energy expenditure, and satiety. BDNF serves as a cell signaling protein, plays key roles in numerous signaling pathways associated with a variety of disorders ranging from depression, schizophrenia, and addiction to obesity and diabetes, and may serve as a hormone. It is perhaps best known for its influence on the formation, growth, survival, and development of neurons and for its role in mediating the beneficial cognitive effects associated with exercise. The decline of BDNF function during aging has important implications for changes to learning and memory in dementia and Alzheimer’s disease. CLICK TO VIEW