Anti-oxidants

Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Anti-oxidants, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may […]

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Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease

Anti-oxidants, Autophagy, Diet and Exercise, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

first_pagesettingsOpen AccessArticle Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease by Hitesh Singh Chaouhan 1,†,Xin Li 1,†,Kuo-Ting Sun 2,3,†,I-Kuan Wang 4,5,Tung-Min Yu 6,7,Shao-Hua Yu 8,Kuen-Bao Chen 9,*,Wei-Yong Lin 10,11,12,* andChi-Yuan Li 1,9,*1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan2Department of Pediatric Dentistry, China Medical University Hospital, Taichung 40402, Taiwan3School of Dentistry, China Medical University, Taichung

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease Read More »

Plant derived bioactive compounds and their potential to enhance adult neurogenesis

Anti-oxidants, Herbs & Spices, Parkinson's Disease, Pre-PD /

Self-renewal and proliferation of neural progenitor cells occur throughout humans’ lives. However, aging, stress, and degenerative diseases can hinder or stop the process. If you can accelerate neurogenesis in adults, this is a promising way to recover from neurodegeneration and cognitive impairments. As the demand for a safer and natural therapeutic product has increased over

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The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

Anti-oxidants, Constipation, Diet and Exercise, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) orParkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has beena permanent challenge to science. New tools were developed over the past two decades andwere immediately incorporated into routines in many laboratories, but the most valuable scientificcontribution was the “waking up” of

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The role of oxidative stress and the underlying biological pathways in the pathogenesis of Parkinson’s Disease

Anti-oxidants, Mitochondria /

The mechanisms involved in pathogenesis and progression ofPD is not fully understood but there is overwhelming evidence thatmaintenance of redox potential is important for neuronal survival.Any disruption in the mitochondrial potential disrupts the cellularhomeostasis, which in turn causes more ROS production leadingto neuroinflammation and degeneration. The review attempts toconsolidate key signaling pathways, and proteins that

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Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models

Anti-oxidants, Diet and Exercise, Parkinson's Disease, Therapies /

Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from

Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models Read More »

Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models

Anti-oxidants, Parkinson's Disease, Pre-PD /

Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from

Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models Read More »

Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome– a pilot study

Anti-oxidants, Butyrate, Gut Microbiota, Metabolites, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

The modulatory effect of vitamins on the gut microbiome and related host health benefits remain largely unclear. We investigated the effects of colon-delivered vitamins A, B2, C, D, and E on the gut microbiota using a human clinical study and batch fermentation experiments, in combination with cell models for the assessment of barrier and immune

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The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols

Anti-oxidants, Gut Microbiota, Polyphenols, Probiotics, Prebiotics and Symbiotics /

Thereby,after selecting, analyzing and debating the main articles on this topic, the bacteria related to the pathogenesis of ALS have been identified, among which we can positively highlight the presence mainly of Akkermansia muciniphila, but also Lactobacillus spp., Bifidobacterium spp. or Butyrivibrio fibrisolvens. Nevertheless, the presence of Escherichia coli or Ruminococcus torques stand out negatively

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Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials

Anti-oxidants, Diet and Exercise, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Author links open overlay panelIn vitro and in vivo studies have associated astaxanthin’s unique molecular features with several health benefits, including neuroprotective, cardioprotective and antitumoral properties, suggesting its therapeutic potential for the prevention or co-treatment of dementia, Alzheimer, Parkinson, cardiovascular diseases and cancer. Benefits on skin and eye health promotion have also been reported, highlighting its

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