Ayahuasca

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Ayahuasca, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Uncategorized /

N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of […]

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Therapeutic Properties of Ayahuasca Components in
Ischemia/Reperfusion Injury of the Eye

Ayahuasca /

Ischemic eye diseases are major causes of vision impairment. Thus, potential retinoprotective effects of N’N-dimethyltryptamine (DMT) were investigated. To inhibit its rapid breakdown bymonoamine-oxidase A (MAO-A) enzyme, DMT was co-administered with harmaline, a β-carbolinein the Amazonian Ayahuasca brew. Using ligation, 60 min of ischemia was provoked in eyes of rats,followed by 7 days of reperfusion

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Ischemia/Reperfusion Injury of the Eye Read More »

Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

Ayahuasca, Gut Microbiota /

There has been a renewed interest in the potential use of psychedelics for the treatment of psychiatric conditions. Nevertheless, little is known about the mechanism of action and molecular pathways influenced by ayahuasca use in humans. Therefore, for the first time, our study aims to investigate the human metabolomics signature after consumption of a psychedelic, ayahuasca, and its connection

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Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084
and DMT, on Neurogenesis and Neuroinflammation in an
Aβ1-42-Injected, Wild-Type Mouse Model of AD

Ayahuasca, Parkinson's Disease /

Alzheimer’s disease (AD) is the most common form of dementia characterized by cognitivedysfunctions. Pharmacological interventions to slow the progression of AD are intensively studied. Apotential direction targets neuronal sigma-1 receptors (S1Rs). S1R ligands are recognized as promisingtherapeutic agents that may alleviate symptom severity of AD, possibly via preventing amyloid-β-(Aβ-) induced neurotoxicity on the endoplasmic reticulum

Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084
and DMT, on Neurogenesis and Neuroinflammation in an
Aβ1-42-Injected, Wild-Type Mouse Model of AD Read More »

The promise of psychedelic research

Ayahuasca, Parkinson's Disease, Pre-PD /

The use of psychedelics as medicines and for overall better brain health is potentially one of the mosttransformative developments given their immediate and long-lasting therapeutic effects across a plethoraof neuropsychiatric disorders and, more recently, some neurodegenerative diseases. The US psychedelicdrugs market is forecasted to grow by 16.3% by 2027 due to the increasing prevalence of

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An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population

Ayahuasca, Breath /

Background Holotropic breathwork (Grof ® Breathwork), was developed by Stanislav Grof and Christina Grof as a ‘non-drug’ alternative technique to evoke altered states of consciousness (ASC). Interestingly, although HBW has been anecdotally reported to evoke experiences and mental health effects corresponding to those of psychedelic substances, the scientific literature on the matter is scarce. Aims

An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population Read More »

Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders

Ayahuasca, Parkinson's Disease, Pre-PD /

Psychedelics are increasingly being recognized for their potential to treat a wide range of braindisorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder.Their broad therapeutic potential might result from an ability to rescue cortical atrophy common tomany neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor geneexpression, activating neuronal growth and survival mechanisms, and

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CORE ONE LABS’ AKOME SEEKS TO REVOLUTIONIZE TREATMENT OF PARKINSON’S DISEASE AND SUBMITS APPLICATION TO PROTECT IP

Ayahuasca, Parkinson's Disease, Pre-PD /

Akome’s AKO004 psychedelic drug formulation, for use in the treatment of Parkinson’s disease, is a composition comprising the psychedelic compound N,N-dimethyltryptamine (DMT) and, a specifically chosen, naturally occurring plant bioactive.  Initial data analysis indicates that the AKO004 composition is safe and efficacious for use, and presents many positive properties which may counter or mitigate neurodegeneration

CORE ONE LABS’ AKOME SEEKS TO REVOLUTIONIZE TREATMENT OF PARKINSON’S DISEASE AND SUBMITS APPLICATION TO PROTECT IP Read More »

Overcoming epistemic injustices in the biomedical study of ayahuasca. Towards ethical and sustainable regulation

Ayahuasca, Parkinson's Disease, Pre-PD /

After decades of biomedical research on ayahuasca’s molecular compounds and theirphysiological effects, recent clinical trials show evidence of therapeutic potential for depression.However, indigenous peoples have been using ayahuasca therapeutically for a very longtime, and thus we question the epistemic authority attributed to scientific studies, proposing thatepistemic injustices were committed with practical, cultural, social and legal

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