Biomarkers

PREMOTOR PARKINSON’S DISEASE: OVERVIEW OF CLINICAL SYMPTOMS AND CURRENT DIAGNOSTIC METHODS

Biomarkers, iRBD, Pre-PD, Symptoms / Diagnosis /

The best known premotor symptoms include hyposmia, REM sleep behavior disorder (RBD), constipation, and depression; other symptoms are excessive daytime somnolence, orthostatic hypotension and symptomatic hypotension, erectile or urinary dysfunction, musculoskeletal symptoms, pain, and global cognitive deficit. In this review, we summarize currently available diagnostic methods for these symptoms. We also briefly summarize neuroimaging, polyneuropathy, […]

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Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease

Biomarkers, Pre-PD, Symptoms / Diagnosis /

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in longitudinal changes in anthropometric and serological indices obtained from health

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Acupoint Massage Therapy Alters the Composition of Gut Microbiome in Functional Constipation Patients

Biomarkers, Gut Dysbiosis, Gut Microbiota, Symptoms / Diagnosis /

The 16S KEGG function prediction suggested that Parkinson disease, retinol metabolism, and arachidonic acid metabolism could explain the biological function of different gut microbiome. Furthermore, cytokines in the serum showed a correlation with the abundance of Pseudobutyrivibrio in CFC. Conclusion. AMT could change the composition of gut microbiome which is associated with cytokines in CFC patients. CLICK TO

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Olfactory impairment as an early marker of Parkinson’s disease in REM sleep behavior disorder: a systematic review and meta-analysis

Biomarkers, iRBD, Olfactory /

We identified similar olfactory impairments in patients with RBD and patients with PD (either with or without underlying RBD). These findings suggest that olfactory impairment may be a sensitive and stable diagnostic biomarker of RBD and appears to be useful for identifying patients with idiopathic RBD at high risk for early conversion to PD. CLICK

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A rapid a-synuclein seed assay of Parkinson’s disease CSFpanel shows high diagnostic accuracy

Biomarkers /

Assays that specifically measure a-synuclein seeding activity inbiological fluids could revolutionize the diagnosis of Parkinson’s disease. Recentimprovements in a-synuclein real-time quaking-induced conversion assays ofcerebrospinal fluid have dramatically reduced reaction times from 5-13 daysdown to 1-2 days.    Click here for report

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A rapid α-synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy

Biomarkers, Library, Parkinson's Disease /

Our improved α-synuclein seed amplification assay dramatically reduces the time needed to diagnose Parkinson’s disease while maintaining the high-performance standards associated with previous α-synuclein seed assays, supporting the clinical utility of this assay for Parkinson’s disease diagnosis.  https://doi.org/10.1002/acn3.51280

A rapid α-synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy Read More »