Biomarkers

Identification of an early-stage Parkinson’s disease neuromarker using event-related potentials, brain network analytics and machine-learning

This pilot study found that BNA can identify patients with early PD using an advanced analysis of ERPs. These results need to be validated in a larger PD patient sample and assessed for people with premotor phase of PD. CLICK TO REVIEW

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Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson’s disease patients

Serum SCFAs are altered in PD patients, and the decrease of serum propionic acid level is correlated with motor symptoms, cognitive ability and non-depressed state. Thus, the gut microbial-derived SCFAs potentially affect Parkinson’s symptoms through the blood circulation. Propionic acid supplementation might ameliorate motor and non-motor symptoms of PD patients, although clinical trials are needed

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Non-Motor Symptoms and Their Associated Factors in Parkinson’s Disease

Background: Parkinson’s disease is a common neurologic ailment that causes tremor and bradykinesia. The prevalenceof Parkinson’s disease is estimated to be 1–2 in 1000, affecting about 1% of the population over the age of 60 years. Theobjective of this study was to find the frequency of Non-Motor Symptoms in patients with Parkinson’s Disease (PD) andits

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MicroRNA Candidate Biomarkers for Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder

Current study provides a valuable and highly informative dataset of EV-associated sncRNAsfrom plasma of iRBD and PD patients. We identified miRNA signature features that could serve asminimally-invasive, blood-based surveillance biomarkers for distinguishing iRBD or PD from healthyindividuals with high sensitivity, specificity, and accuracy. CLICK TO REVIEW

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Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort

This study provides new information on the longitudinal development of ΔSBP in patients with PD with distinct trajectories of rapidly increasing, low-stable, and high-stable class. Male sex, lower supine DBP, and lower total proteins helped to identify the class with increasing risk for OH. Further research is needed to discover the biological mechanisms that explain

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Validation of cepstral peak prominence in assessing early voice changes of Parkinson’s disease: Effect of speaking task and ambient noise

ABSTRACT Although the cepstral peak prominence (CPP) and its variant, the cepstral peak prominence smooth (CPPS), are considered to be robust acoustic measures for the evaluation of dysphonia, whether they are sensitive to capture early voice changes in Parkinson’s disease (PD) has not yet been explored. This study aimed to investigate the voice changes via

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Environmental triggers of Parkinson’s disease – Implications of the Braak and dual-hit hypotheses

Idiopathic Parkinson’s disease (PD) may take decades to develop, during which many risk or protective factors may come into play to initiate the pathogenesis or modify its progression to clinical PD. The lack of understanding of this prodromal phase of PD and the factors involved has been a major hurdle in the study of PD

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Possible predictors of phenoconversion in isolated REM sleep behaviour disorder: a systematic review and meta-analysis

Background A number of promising biomarkers for predicting imminent α-synucleinopathies have been suggested in isolated rapid eye movement sleep behaviour disorder (iRBD). However, existing evidence is conflicting without quantitative evaluation. Methods PubMed, Web of Science and ClinicalTrials.gov were searched through June 2021 to identify possible predictors of phenoconversion from iRBD to Parkinson’s disease (PD). The pooled HRs

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Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s diseas

The proximity ligation assay (PLA) is a specific and sensitive technique for the detection of αSyn oligomers (αSyn-PLA), early and toxic species implicated in the pathogenesis of PD. We aimed to evaluate by skin biopsy the diagnostic and prognostic capacity of αSyn-PLA and small nerve fiber reduction in PD in a longitudinal study. αSyn-PLA was

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The role of probiotics in nutritional health: probiotics as nutribiotics

The gut microbiota has gained importance through the years due to its significant influences on the maintenance of human health. A wide variety of microorganisms shape this gut microbiota, which preserves health with the modulation of the immune system, enhancement of the nutrients absorption, or the protection against pathogens’ colonization. The disruption of this microenvironment

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