Biomarkers

Alpha-synuclein preformed fibrils: a tool to understand Parkinson’s disease and develop disease modifying therapy

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by multiple motor and non-motor symptoms, which include, among others, constipation, sleep disturbance, bradykinesia, gait and balance abnormalities, muscle stiffness and resting tremor. The motor symptoms are caused by progressive age-related death of dopaminergic neurons and in the vast majority of patients suffering from […]

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Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease

A-Synuclein, Biomarkers, Pre-PD /

In human post-mortem liver tissue, we identifed cases with neuropathologically confrmed α-syn pathology containing α-syn within hepatocellular structures to a higher degree (75%) than control subjects without α-syn accumulation in the brain (57%). Our results reveal that α-syn accumulates within the liver and may be derived from the brain or other peripheral sources. Collectively, our

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Biomarkers and the Role of α-Synuclein in Parkinson’s Disease

A-Synuclein, Biomarkers, Pre-PD /

This review article aims to summarize useful biomarkers for the diagnosis of PD, as well as the biomarkers used to monitor disease progression. This review article describes the role of α-Syn in PD and how it could potentially be used as a biomarker for PD. Also, preclinical and clinical investigations encompassing genetics, immunology, fluid and

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Dietary restrictions modulate the gut microbiota: Implications for health and disease

Biomarkers, Butyrate, Diet and Exercise, Gut Permeability / Leaky Gut, Gut-Brain axis /

The data suggests that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression of several diseases such as obesity, diabetes, neurological diseases or inflammatory bowel disease. Finally, the relevance of the findings for clinical practice is evaluated and approaches for future research are proposed. CLICK TO REVIEW

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Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila

A-Synuclein, Biomarkers, Pre-PD /

Taken together, our results presented here indicate α-syn accumulation in presynaptic terminals affects synaptic proteins and active zone integrity that impair neuronal function. The resultant synaptopathy causes behavioural deficits and progressive age-related neurodegeneration. Thissuccession of phenotypes recapitulates key events of dying-back like neurodegeneration5,27,92 and provide insights into the pathogenic mechanisms underlying synaptopathy, the likely initiating

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Nutritional aspects in Parkinson’s disease

Biomarkers, Diet and Exercise, Parkinson's Disease, Pre-PD /

The links between diet and Parkinson’s disease (PD) are unclear and incomprehensible. However, numerous studies have demonstrated the correlation between diet, nutrients and health condition in PD patients. They indicate the possibility of management of the disease, which might be possible through nutrition. Pharmaceutical treatment as well as a complementary holistic approach to the patients

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PPMI 2.0 Clinical -Establishing a Deeply Phenotyped PD Cohort (PPMI)

Biomarkers, iRBD, Symptoms / Diagnosis /

The Parkinson Progression Marker Initiative 2.0 (PPMI 2.0) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson’s disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls The overall goal of PPMI 2.0 is to identify

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The gut microbiota metabolite propionate ameliorates intestinal epithelial barrier dysfunction-mediated Parkinson’s disease via the AKT signaling pathway

Biomarkers, Butyrate, Gut Microbiota, Short Chain Fatty Acids /

Our results demonstrated that propionate, which was decreased in the fecal samples of Parkinson’s disease patients, exerted beneficial effects on intestinal epithelial barrier function and improved motor behavior in MPTP-induced Parkinson’s disease mice through the AKT signaling pathway. CLICK TO REVIEW

The gut microbiota metabolite propionate ameliorates intestinal epithelial barrier dysfunction-mediated Parkinson’s disease via the AKT signaling pathway Read More »

Autonomic disorders predicting Parkinson disease

Biomarkers, Constipation, iRBD, Pre-PD /

There is evidence that constipation, urinary and sexual dysfunction and more recently decreased cardiac chronotropic response during exercise, are part of the premotor parkinsonian phenotype. The sensitivity and specificity of these features has yet to be accurately assessed. We briefly review the evidence for autonomic dysfunction as biomarker of premotor PD. CLICK TO REVIEW

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The microbiota–microglia axis in central nervous system disorders

Biomarkers, Butyrate, Gut Microbiota, Pre-PD, Short Chain Fatty Acids /

Host microbiota are mostly residing in the gut and contribute to microglial activation states, for example, via short-chain fatty acids (SCFAs) or aryl hydrocarbon receptor (AhR) ligands. Thereby, the gut microorganisms are deemed to influence numerous CNS diseases mediated by microglia.In this review, we summarize recent findings of the interaction between the host microbiota and

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