Constipation

Clinical therapeutic effects of probiotics in patients with constipation associated with Parkinson disease

Constipation, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Constipation is the most predominant symptom of Parkinson disease (PD), preceding the occurrence of motor symptoms in some patients, leading to reduced quality of life (QOL). The general approaches for the treatment have some side effects, but probiotics are live or attenuated microorganisms attributed to ameliorating constipation effects. Moreover, as treatments are generally well tolerated and side […]

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Gastrointestinal dysfunction in Parkinson’s disease.

A-Synuclein, Constipation, Gut Dysbiosis, Gut Microbiota, Oral Microbiome /

Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson’s disease has increased substantially in the past decade. The entire gastrointestinal tract is affected in these patients, causing complications that range from oral issues, including drooling and swallowing problems, to delays in gastric emptying and constipation. Additionally, small intestinal bacterial overgrowth and Helicobacter

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Early constipation predicts faster dementia onset
in Parkinson’s disease

Constipation, Dementia - Lewy Bodies /

Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may bepart of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration,composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessedwith the MDS-UPDRS

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in Parkinson’s disease Read More »

Fecal microbiota transplant as a potential treatment for Parkinson’s disease – A case series

Constipation, Fecal Transplants (FMT) /

In this preliminary uncontrolled case series of 6 PD patients, a treatment with donor FMT infused via colonoscopy, was safe and resulted in improvement of PD motor and non-motor symptoms, including constipation, at 6 months. Further research is needed to assess longer-term maintenance of efficacy and safety, including in large scale randomized controlled trials. CLICK TO

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Gut Microbiome Changes with Osteopathic Treatment of Constipation in Parkinson’s Disease: A Pilot Study

Biomarkers, Constipation, Gut Microbiota /

The gut microbiome shifted among individuals with constipation and PD after four weekly treatments with the OMM-sequence. Changes in the gut microbiome Post-OMM were associated with UPDRS results and constipation measures. Clinical trials and studies to develop the gut microbiome into a validated biomarker for PD are necessary to understand the impact of OMM in

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Parkinson’s is announced long before the diagnosis

Constipation, iRBD, Olfactory, Sleep /

Parkinson’s disease is a progressive disease of the brain caused by the death of special nerve cells. The disease is characterized by movement disorders such as slowing movements, stiffness of the muscles, tremors or specific changes in the gait pattern. Often there can be many years before these typical symptoms permit a diagnosis of Parkinson’s disease. These can

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Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease

Constipation, Probiotics, Prebiotics and Symbiotics /

This study showed that consumption of a multi-strain probiotic (Hexbio®) over 8 weeks improved bowel opening frequency and whole gut transit time in PD patients with constipation. CLICK TO REVIEW

Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease Read More »

Autonomic disorders predicting Parkinson disease

Biomarkers, Constipation, iRBD, Pre-PD /

There is evidence that constipation, urinary and sexual dysfunction and more recently decreased cardiac chronotropic response during exercise, are part of the premotor parkinsonian phenotype. The sensitivity and specificity of these features has yet to be accurately assessed. We briefly review the evidence for autonomic dysfunction as biomarker of premotor PD. CLICK TO REVIEW

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Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut–Brain Axis

Constipation, Gut-Brain axis, Pre-PD, Probiotics, Prebiotics and Symbiotics, Vagal Nerve /

The hypothalamic–pituitary–adrenal axis was modulated by PS128 with decreased corticosterone concentration in serum and the expression of mineralocorticoid receptors in the amygdala. Oral administration of PS128 inhibited 5-HTPinduced VH during CRD. The ameliorative effect on VH suggests the potential application of PS128 for IBS. CLICK TO REVIEW

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