Dementia – Lewy Bodies

Early constipation predicts faster dementia onset
in Parkinson’s disease

Constipation, Dementia - Lewy Bodies /

Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may bepart of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration,composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessedwith the MDS-UPDRS […]

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in Parkinson’s disease Read More »

Motor Dysfunction in REM Sleep Behavior Disorder: A Rehabilitation Framework for Prodromal Synucleinopathy

A-Synuclein, Dementia - Lewy Bodies, Diet and Exercise, iRBD, Pre-PD /

The proposed rehabilitation framework for iRBD includes early exercise-based interventions of aerobic exercise, progressive resistance training, and multimodal exercise with rehabilitation consultations to address exercise prescription, progression, and monitoring. This rehabilitation framework may be used to implement neuroprotective, multidisciplinary, and proactive clinical care in people with a high likelihood of conversion to PD, dementia with

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Metals associated neurodegeneration in Parkinson’s disease: Insight to physiological, pathological mechanisms and management

A-Synuclein, Dementia - Lewy Bodies, Iron, Parkinson's Disease, Pre-PD /

 There is increasing evidence that heavy metals normally present in the human body in minute concentration also cause accumulation to initiate the free radical formation and affecting the basal ganglia signaling. In this review, we explored how these metals affect brain physiology and their roles in the accumulation of toxic proteins (α-synuclein and Lewy bodies).

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An Overview of Alpha Synuclein Protein and Its Role in Parkinson’s disease

A-Synuclein, Dementia - Lewy Bodies, Uncategorized /

Under pathologic conditions, cellular accumulation of misfolded α-synuclein oligomers and aggregates are observed in a group of neurodegenerative diseases called synucleinopathies. The mechanisms of how α-synuclein protein takes part in the neurodegeneration process and physiologic roles of the protein have not been fully elucidated yet. It’s important to unravel the secrets of this protein and

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Impact of rapid eye movement sleep behavior disorder and autonomic disorders on Parkinson’s disease

Biomarkers, Dementia - Lewy Bodies, iRBD, Symptoms / Diagnosis /

This article aimed at critically reviewing the literature on the controversies about the prevalence of RBD in PD, the higher incidence of PD non-motor symptoms associated with RBD, the evidence of faster motor worsening in parkinsonian patients with this parasomnia, and the main pathophysiological hypotheses that support these findings. CLICK TO REVIEW

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Study reveals close link between Parkinson’s disease and certain immune cells in the blood

Biomarkers, Dementia - Lewy Bodies, iRBD, Pre-PD /

The researchers have studied a group of patients suffering from REM Sleep Behavior Disorder (RBD), a condition where the patients physically act vivid dreams with vocalizations and movements. If a patient e.g. dreams that they are running, their legs will move as if they were actually running. The sleep disorder is often discovered by a

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Objective sleep data as predictors of cognitive decline in dementia with Lewy Bodies and Parkinson’s disease

Dementia - Lewy Bodies, iRBD, Pre-PD /

Our data suggests that PSG data can be useful in predicting cognitive decline in PD but not in DLB patients. In PD patients, an RBD diagnosis is predictive of cognitive deterioration, confirming the notion that this non-motor symptom relates to a malignant sub-type. Tonic excessive muscular activity, but not other RBD features, had predictive value in

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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

A-Synuclein, Biomarkers, Dementia - Lewy Bodies, iRBD, Pre-PD /

In patients with IRBD, RT-QuIC detects misfolded α-synuclein in the CSF with both sensitivity and specificity of 90%, and α-synuclein positivity was associated with increased risk of subsequent diagnosis of Parkinson’s disease or dementia with Lewy bodies. Detection of α-synuclein in the CSF represents a potential prodromal marker of Parkinson’s disease and dementia with Lewy bodies. If

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study Read More »