Brain-derived neurotrophic factor, or BDNF, is a growth factor with broad relevance for aging, brain function, behavior, metabolism, energy expenditure, and satiety. BDNF serves as a cell signaling protein, plays key roles in numerous signaling pathways associated with a variety of disorders ranging from depression, schizophrenia, and addiction to obesity and diabetes, and may serve […]
Brain-derived neurotrophic factor (BDNF) Read More »
Sleep is one of the great mysteries of life. For a long time, it was widely thought that sleep was little more than a waste of time. Modern research, however, has shed much-needed light on the matter, showing sleep is a crucial component of a healthy lifestyle, and that lack of sleep can have far-reaching
Top 33 Tips to Optimize Your Sleep Routine Read More »
Given the tremendous amount of evidence linking neuroinflammation with neural dysfunction, it is no surprise that the Western diet has been implicated in the development of many diseases and disorders of the brain, including memory impairments, neurodegenerative disorders, and depression. In this review, we discuss each of these concepts to understand how what we eat
Analyses revealed a significant direct effect of anxiety predicting cognitive functioning. Additionally, there was a significant indirect within-person effect; meaning that individuals who became more anxious over time, they also reported becoming less physically active, which was subsequently associated with longitudinal declines in cognitive functioning. CLICK TO REVIEW
Chronic or intermittent food restriction has profound effects in shaping brain and peripheral metabolism, immunity, and gut microbiome biology. Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases Read More »
We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases. CLICK TO REVIEW
The improvement in information processing following aerobic exercise, but not levodopa administration, suggests high intensity exercise may be enhancing neural processing and non-motor pathways outside those impacted by medication. The persistence of symptom improvement despite exercise intervention cessation indicates exercise is a candidate for disease modification. CLICK TO REVIEW
Neurodegenerative diseases are becoming a big challenge for modern society. Neurodegenerative disorders strongly impact on patient and their caregivers. Moreover, since the population is becoming older, these pathologies will deeply influence medical and socio-economic conditions in the next years. CLICK TO REVIEW
Novel perspectives for neurodegeneration prevention: effects of bioactive polyphenols Read More »
A large and convincing body of evidence demonstrated that aging is characterized by a progressive decline in the efficiency of physiological functions due to the consequence of free radical-induced damage to cellular macromolecules. https://doi.org/10.1155/2018/3416028
The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson’s disease (PD) progression. These are the first data to provide evidence that targeted nutrition is associated with the rate of PD progression. https://doi.org/10.1155/2017/6405278
Role of Diet and Nutritional Supplements in Parkinson’s Disease Progression Read More »