Gut dysbiosis can affect brain immune homeostasis through the microbiota–gut–brain axis and can play a key role in the pathogenesis of neurodegenerative diseases, including dementia and Alzheimer’s disease (AD). The relationship between gut dysbiosis and AD is still elusive, but emerging evidence suggests that it can enhance the secretion of lipopolysaccharides and amyloids that may […]
Based on available evidence, exogenous ketogenic agents may be more feasible than dietary interventions in NDD from a compliance and adherence perspective; more research is required to confirm this. Recommendations for future research include improving exogenous formulations to reduce adverse effects, exploring interindividual factors affecting response-to-treatment, and establishing a “minimum required dose” for clinically meaningful
Author links open overlay panelIn vitro and in vivo studies have associated astaxanthin’s unique molecular features with several health benefits, including neuroprotective, cardioprotective and antitumoral properties, suggesting its therapeutic potential for the prevention or co-treatment of dementia, Alzheimer, Parkinson, cardiovascular diseases and cancer. Benefits on skin and eye health promotion have also been reported, highlighting its
Winter nordic walking as multitask is the effective measure of exercise treatment in patients with PD, because it improves the spatial-temporal characteristics of walking and the motor function. CLICK TO REVIEW
Nordic walking in winter as the multitask training in patients with Parkinson’s disease Read More »
Conclusion: Distinct PA profiles, with clear differences in how the time awake is spent exist among people withmild-moderate PD. CLICK TO REVIEW
Physical activity profiles in Parkinson’s disease Read More »
Our study demonstrates that ITF-prebiotic intake during 3 months decreases a fecal marker of intestinal inflammation in obese patients. Our data point to a potential contribution of microbial lipid-derived metabolites in gastro-intestinal dysfunction related to obesity. CLICK TO REVIEW
In this review, we briefly summarize recent findings and analyze the application of molecular metabolomics in familial and sporadic PD from genetic mutations, mitochondrial dysfunction, and dysbacteriosis. We also review metabolic biomarkers to assess the functional stage and improve therapeutic strategies to postpone or hinder the disease progression. CLICK TO REVIEW
Advances of Mechanisms-Related Metabolomics in Parkinson’s Disease Read More »
The improvements in SVaD-IF mice suggest that IF could be a potential nonpharmacological remedy for SVaD. This finding could stimulate future investigations on IF’s neuroprotective potential across many neurovascular diseases. CLICK TO REVIEW
As a member of the neurotrophin family, BDNF regulates many of the processes within neurogenesis, such as differentiation and survival. Although much more is known about the direct role that exercise and BDNF have on hippocampal neurogenesis in rodents, their corresponding cognitive benefits in humans will also be discussed. Specifically, what is known about exercise-mediated
Exercise-Mediated Neurogenesis in the Hippocampus via BDNF Read More »
BDNF (the acronym for brain-derived neurotrophic factor) is a protein produced in high quantities in the central nervous system. It plays a part in regulating the structure, function, and development of the neurons and synapses that form your brain’s internal communication network. While BDNF levels are highest in childhood when the brain is rapidly developing,
Top 10 Foods to Boost Your BDNF Read More »