Endotoxin

Periapical Disease and the Prefrontal Cortex. Is there a Relationship between Calcium-Binding Protein and Neurodegenerative Diseases?

endondonics, Endotoxin, Periodontitis /

Apical periodontitis (AP) or periapical lesion (PL) is an inflammatory disease that causes pain, loss of bone and destruction of other tissues of teeth support. This condition could be caused by caries, dental trauma and/or periapical microleakage wich is regulated by the immune system or inflammatory response. Several analyses have shown that endodontic infection can […]

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Environmental neurotoxicants and inflammasome activation in Parkinson’s disease – a focus on the gut-brain axis

Detox, Endotoxin, Gut-Brain axis, Vagal Nerve /

Inflammasomes are multi-protein complexes expressed in immune cells that function as intracellular sensors of environmental, metabolic and cellular stress. Inflammasome activation in the brain, has been shown to drive neuropathology and disease progression by multiple mechanisms, making it one of the most attractive therapeutic targets for disease modification in Parkinson’s Disease (PD). Extensive inflammasome activation

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Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

A-Synuclein, Endotoxin, Parkinson's Disease, Pre-PD /

Thoughts – Just maybe we are finding the mechanics behind the 2+ theory of PD which states that 2 or more variables must come about in order PD to progress into diagnosisable PD. Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble

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Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life

Endotoxin, Lipopolysaccharides (LPS), Root Canal /

CAP-related depression was accompanied by increased levels of NOx, LOOH, AOPP, and TRAP. In CAP participants, there was a strong correlation (r = 0.734, p < 0.001) between root canal LPS and the HDRS score. There were significant and positive associations between CAP or root canal endotoxin with the vegetative and physiosomatic symptoms of the

Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life Read More »