ENS

Functional imaging of the brainstem during visually-guided motor control reveals visuomotor regions in the pons and midbrain

A-Synuclein, ENS /

Visuomotor activity during visually-guided pinch-grip force was measured while controlling for force without visual feedback activity and visual stimuli without force activity in healthy adults. Using physiological noise correction and multiple task repetitions, we demonstrated that visuomotor activity occurs in the inferior portion of the basilar pons and the midbrain. These findings provide direct evidence […]

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The Aged Intestine: Performance and Rejuvenation

Biomarkers, ENS, Gut Permeability / Leaky Gut /

Owing to the growing elderly population, age-related problems are gaining increasing attention from the scientific community. With senescence, the intestine undergoes a spectrum of changes and infirmities that are likely the causes of overall aging. Therefore, identification of the aged intestine and the search for novel strategies to rescue it, are required. Although progress has

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Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins

A-Synuclein, ENS, Vagal Nerve /

In this work, we investigated the ability of amyloid fibrils derived from two food proteins to heterologously seed the aggregation of the PD-related aSyn protein. While β-lactoglobulin amyloid fibril seeds were not able to induce aSyn aggregation, we identified a fibril surface–mediated nucleation mechanism for the seeding of aSyn aggregation by hen egg white lysozyme

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