Enviromental

Phenoconversion Risk Factors in Rapid Eye Movement Sleep Behavior Disorder

Biomarkers, Enviromental, iRBD, Parkinson's Disease, Pesticides, Pre-PD /

A multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD) was studied to determine any predictive factors for α-synuclein–related neurodegenerative illnesses. At the start of the study, patients with iRBD from 12 different sites were given a complete assessment for potential environmental and lifestyle risk factors using a standardized questionnaire. Patients were then […]

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Environmental factors shaping the gut microbiome in a Dutch population

Diet and Exercise, Enviromental, Gut Dysbiosis, Gut Microbiota, Metabolites, Parkinson's Disease /

The gut microbiome is associated with diverse diseases1,2,3, but a universal signature of a healthy or unhealthy microbiome has not been identified, and there is a need to understand how genetics, exposome, lifestyle and diet shape the microbiome in health and disease. Here we profiled bacterial composition, function, antibiotic resistance and virulence factors in the

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Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis?

Enviromental, Glyphosate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Environmental exposure to glyphosate and glyphosate-based herbicides has the potential to negatively influence neurodevelopment and behavior across generations indirectly through the gut-brain-microbiome axis. Potential mechanisms by which glyphosate may elicit these effects are through the disruption of the normally symbiotic relationship of the host and the gut microbiome. Given glyphosate can kill commensal members of

Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis? Read More »

Impact of environmental toxicants exposure on gut-brain axis in Parkinson disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson disease (PD) is a major public health challenge as many of the current drugs used in its management provide symptomatic relieve without preventing the underlying cause of the neurodegeneration. Similarly, the non-motor complications of PD, especially the gastrointestinal tract (GIT) disturbance increases the disease burden on both the PD patient and caregivers. Different theories

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Food Contamination: An Unexplored Possible Link between
Dietary Habits and Parkinson’s Disease

Diet and Exercise, Enviromental, Glyphosate, Lectins, Parkinson's Disease, Pesticides /

Importance of a healthy lifestyle in maintaining the population’s well-being and health,especially in terms of balanced nutrition, is well known. Food choice of and dieting habits couldimpact disease management, which is especially true for Parkinson’s disease (PD). However, nowadays, it is not that simple to maintain a balance in nutrition, and the idea of a

Food Contamination: An Unexplored Possible Link between
Dietary Habits and Parkinson’s Disease Read More »

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Oral Microbiome, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Microbial alterations within the gut microbiome appear to be a common feature of individuals with Parkinson’sdisease (PD), providing further evidence for the role of the gut-brain axis in PD development. As a major site ofcontact with the environment, questions have emerged surrounding the cause and effect of alterations to the gutmicrobiome by environmental contaminants associated

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease Read More »

Microbial pathogens induce neurodegeneration in Alzheimer’s disease mice: protection by microglial regulation

Enviromental, Parkinson's Disease, Root Canal, Viral / Bacterial Infections, Virus /

Exposure to systemic infections causes neurodegeneration in brain regions displaying amyloid pathology and high local microglia density. AD brains exhibit increased susceptibility to microbial PAMPs’ neurotoxicity, which accelerates neuronal death. Microglial modulation protects the brain from microbial TLR agonist PAMP-induced neurodegeneration. CLICK TO REVIEW

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Environmental factors in Parkinson’s disease: New insights into the molecular mechanisms

A-Synuclein, Enviromental /

Parkinson’s disease is a chronic, progressive neurodegenerative disorder affecting 2–3% of the population ≥65 years. It has long been characterized by motor impairment, autonomic dysfunction, and psychological and cognitive changes. The pathological hallmarks are intracellular inclusions containing α-synuclein aggregates and the loss of dopaminergic neurons in the substantia nigra. Parkinson’s disease is thought to be caused by a combination

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