Fasting

Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease.Prevention of neuroinflammation in Parkinson’s disease

Diet and Exercise, Fasting, Parkinson's Disease, Therapies /

Parkinson’s disease (PD) is the second most common age-associated neurodegenerative disorder and is characterized by progressive loss of dopamine neurons in the substantia nigra. Peripheral immune cell infiltration and activation of microglia and astrocytes are observed in PD, a process called neuroinflammation. Neuroinflammation is a fundamental response to protect the brain but, when chronic, it […]

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Effects of Intermittent Fasting On Cognition and
Neurodegeneration

Fasting, Parkinson's Disease /

Intermittent fasting (IF) can facilitate neurodegenerative, neuroadaptive and neuroprotective processes leading toprofound effects on cognition and dementias. The impact that IF has on the central nervous system is still not fullyknown. Several factors come into likely effect including changes in energy metabolism, oxidative damage, insulinsensitivity, inflammation, and functional changes related to various neurotransmitters and hormones.

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The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Fasting /

Intermittent fasting (IF) has been studied for its effects on lifespan and lifespan as well as the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria participate in key metabolic pathways and play important roles in maintaining intracellular signaling networks that modulate various cellular functions. Mitochondrial dysfunction has been described as

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Is Fasting Good For Your Brain? The Effects of Fasting on the Brain

Autophagy, Fasting, Parkinson's Disease, Pre-PD /

Fasting promotes autophagy, a vital recycling process, and stimulates the growth factor BDNF. Autophagy is impaired in neurodegenerative conditions such as Alzheimer’s and Parkinson’s. BDNF is crucial for brain health, and low levels are associated with depression. Hence, fasting improves brain health by multiple mechanisms. While fasting has been performed in one form or another

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Metabolic Strategies in Healthcare: A New Era

Diet and Exercise, Fasting, Mitochondria /

Modern healthcare systems are founded on a disease-centric paradigm, which has conferred manynotable successes against infectious disorders in the past. However, today’s leading causes of death are dominatedby non-infectious “lifestyle” disorders, broadly represented by the metabolic syndrome, atherosclerosis, cancer,and neurodegeneration. Our disease-centric paradigm regards these disorders as distinct disease processes,caused and driven by disease targets

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The Effects of Intermittent Fasting on Brain and Cognitive Function

Fasting, Parkinson's Disease /

The importance of diet and the gut-brain axis for brain health and cognitive function isincreasingly acknowledged. Dietary interventions are tested for their potential to prevent and/ortreat brain disorders. Intermittent fasting (IF), the abstinence or strong limitation of calories for 12to 48 hours, alternated with periods of regular food intake, has shown promising results on neurobiological

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Fasting: How to Guide

Diet and Exercise, Fasting /

Fasting potentials are the most interesting topics in the Nutritional Era. Fasting consists of the catabolism of lipids, proteins, and carbohydrates to maintain blood glucose levels in a normal range. The action mechanisms of fasting were firstly understood in minor organisms and later in humans. Nutritional interventions of caloric restriction could attenuate age-associated epigenetic alterations

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Ketogenic Diet and Health

Diet and Exercise, Fasting /

In recent years, emerging evidence suggests KD’s may also have therapeutic benefits for some cancers and for neurological conditions such asAlzheimer’s disease, Parkinson’s’ disease, multiple sclerosis, traumatic brain injury, and spinal cord injury. Finally, as the physiological mechanisms by which a KD operates become increasingly understood, we speculate that several other health conditions (e.g., autism,

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Intermittent metabolic switching, neuroplasticity and brain health

Fasting /

Here, we consider how intermittent metabolic switching, repeating cycles of a metabolic challenge that induces ketosis (fasting and/or exercise) followed by a recovery period (eating, resting and sleeping), may optimize brain function and resilience throughout the lifespan, with a focus on the neuronal circuits involved in cognition and mood. Such metabolic switching impacts multiple signalling

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Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men

Fasting, Iron /

Eight days of total starvation diet affected the body composition and decreased exercise capacity. Further, fasting decreased the expression of genes associated with iron storage and export, and increased the expression of genes involved in iron acquisition. Conversely, only PCBP2 protein increased after fasting; however, an upward trend was apparent for all proteins. In conclusion,

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