Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects
Rapid eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, isan early clinical symptom of alpha-synucleinopathies. RBD also defines more severe forms of alphasynucleinopathies. The genetic background of RBD and its underlying mechanisms are not wellunderstood. Here, we performed the first genome-wide association study of RBD, identifying five RBD riskloci. Expression […]