Gut-Brain axis

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Ayahuasca, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Uncategorized /

N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of […]

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Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease

A-Synuclein, Gut-Brain axis, iRBD /

Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson’s disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein and glymphatic system dysfunction. However, evidence accumulating primarily based on clinical data to support glymphatic system dysfunction in patients with iRBD and PD is

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Quantitative and correlational analysis of gut-brain axis in
schizophrenia spectrum and mood disorders

Gut-Brain axis, Oral Microbiome /

The pathophysiology of schizophrenia spectrum disorders and associated mood disordersis complex and highly heterogeneous, suggesting that different molecular pathways are involvedin it. Among those, the microbiome and its connection to the brain (“gut-brain axis”) has emergedas a highly promising research avenue. To evaluate the role of the human microbiome in the gutbrain axis, we evaluated

Quantitative and correlational analysis of gut-brain axis in
schizophrenia spectrum and mood disorders Read More »

Metabolites from the Gut Microbiota and the Role in the
Gut-Brain Axis

Butyrate, Gut Microbiota, Gut-Brain axis, Short Chain Fatty Acids /

The gut microbiota is highly capable of biotransformation, exposing the host to a wide varietyof physiologically active compounds. These metabolites participate in signaling between thegastrointestinal tract and the central nervous system and may regulate physiological andpathological processes in the central nervous system. This bidirectional communication cantake place in a variety of ways, including binding to

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Gut-Brain Axis Read More »

Microbiota in health and diseases

Gut Microbiota, Gut-Brain axis /

The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on thelocalized regions, microbiota can be classified into gut, oral, respiratory, and skin microbiota. The microbial communities are insymbiosis with the host, contributing to homeostasis and regulating immune function. However, microbiota dysbiosis can lead todysregulation of bodily

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Parkinson’s Disease: A Prionopathy?

A-Synuclein, Biomarkers, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis /

The principal pathogenic event in Parkinson’s disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal loss in specific brain regions. Over the last few years, a revolutionary theory has correlated Parkinson’s disease and other neurological disorders with a shared

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Aging Microbiota-Gut-Brain Axis in Stroke Risk
and Outcome

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Stroke /

The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbes and theirhost. Many environmental and host-related factors affect the gut microbiota. Dysbiosis is defined as compositional andfunctional alterations of the gut microbiota that contribute to the pathogenesis, progression and treatment responses todisease. Dysbiosis occurs when perturbations of microbiota composition and function exceed the ability

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and Outcome Read More »

Modulation of gut health using probiotics: the role of probiotic effector molecules

Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Probiotics affect intestinal metabolism and play a crucial role in gut homeostasis. Studies on probiotic effector molecules—bacteriocins, peptidoglycan, teichoic acid, exopolysaccharides, secretory proteins, and short-chain fatty acids—describe their effect on the gut barrier; immune and nervous system; and gut microbiota. However, the detailed mechanism of how the intestinal microbiota changes after the intervention of effector

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Probiotics in Health and Disease: A Review of Emerging
Evidence of Potential Benefits and Harm

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Emerging multi-drug resistant pathogens are the main driving force behind the efforts to find analternative treatment approach such as probiotics. Probiotics are considered living drugs that can reduce theconsumption of conventional antibiotics and improve human and animal health. Particularly, bacterial originprobiotics became increasingly popular during the last two decades as a result of the continuously

Probiotics in Health and Disease: A Review of Emerging
Evidence of Potential Benefits and Harm Read More »

Gut–Brain Cross Talk: Microbiome
and Micronutrients

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

A good diet may deliver micronutrients such as vitamins A, B6, B12, C,and D and minerals such as iron, copper, zinc, and selenium that have beenimplicated to have key roles for supporting immunity with reducing host infections.Most studies have shown that once the subject was infected, the immune system willbe enhanced, which will require high

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and Micronutrients Read More »