Gut-Brain axis

Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS

Biomarkers, Constipation, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Vagal Nerve /

The recent revelation that the gut microbiome, home to approximately 100 trillion microorganisms, is implicated in the development of both health and disease has spurred an exponential increase in interdisciplinary research involving gut microbiology. In all this hype, there is a need to better understand and contextualize the emerging evidence for the role of the gut microbiota in […]

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Deciphering the prion-like behavior of pathogenic protein aggregates in neurodegenerative diseases

A-Synuclein, Autonmic nervous system, Biomarkers, Gut-Brain axis /

Neurodegenerative diseases are hitherto classified based on their core clinical features, the anatomical distribution of neurodegeneration, and the cell populations mainly affected. On the other hand, the wealth of neuropathological, genetic, molecular and biochemical studies have identified the existence of distinct insoluble protein aggregates in the affected brain regions. These findings have spread the use of a

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Parkinson’s disease: Are gut microbes involved?

Biomarkers, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

Parkinson’s disease (PD) isa common neurodegenerative disorder characterized by motor and gastrointestinal(GI) deficits. Despite its prevalence, the pathophysiology of PD is not wellunderstood. Recent studies highlight the role of gut microbiota in neurologicaldisorders. In this review, we summarize the potential role of gut microbiota inthe pathophysiology of PD. We first describe how gut microbiota can

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Impact of Contaminants on Microbiota: Linking the Gut–Brain
Axis with Neurotoxicity

Autonmic nervous system, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

: Over the last years, research has focused on microbiota to establish a missing link betweenneuronal health and intestine imbalance. Many studies have considered microbiota as criticalregulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system ismainly explained through three different pathways: the neural, endocrine, and immune pathways,intricately interconnected with each

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Axis with Neurotoxicity Read More »

Gut–Brain Axis: Role of Gut Microbiota in Neurodegenerative Disease

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The role of gut bacteria in neurodegenerative disease has long been speculated; however, the extent of influence and the exact composition of microflora that mechanistically alter outcomes are less understood. While aging was thought to be a major contributor to neurodegenerative disease, the role of the immune system started to become more appreciated bringing the

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Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

Butyrate, Gut-Brain axis, Short Chain Fatty Acids /

The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in

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Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease is characterized by motor and non-motor symptoms, such as defects in the gut function, which may occur before the motor symptoms. To date, there are therapies that can improve these symptoms, but there is no cure to avoid the development or exacerbation of this disorder. Dysbiosis of gut microbiota could have a crucial

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A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The human body is full of an extensive number of commensal microbes, consisting of bacteria, viruses, and fungi, collectively termed the human microbiome. The initial acquisition of microbiota occurs from both the external and maternal environments, and the vast majority of them colonize the gastrointestinal tract (GIT). These microbial communities play a central role in

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Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach

Detox, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson’s Disease (PD) is a neurodegenerative disease, leading to motor and nonmotor complications. Autonomic alterations, including gastrointestinal symptoms, precede motordefects and act as early warning signs. Chronic exposure to dietary, environmental heavy metalsimpacts the gastrointestinal system and host-associated microbiome, eventually affecting the centralnervous system. The correlation between dysbiosis and PD suggests a functional and bidirectionalcommunication

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Homeostatic regulation of neuronal excitability by probiotics in male germ-free mice

Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Emerging evidence indicates that probiotics can influence the gut–brain axis to ameliorate somatic and behavioral symptoms associated with brain disorders. However, whether probiotics have effects on the electrophysiological activities of individual neurons in the brain has not been evaluated at a single-neuron resolution, and whether the neuronal effects of probiotics depend on the gut microbiome

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