Idiopathic Parkinson’s disease (PD) may take decades to develop, during which many risk or protective factors may come into play to initiate the pathogenesis or modify its progression to clinical PD. The lack of understanding of this prodromal phase of PD and the factors involved has been a major hurdle in the study of PD […]
Gut microbiota is showing and raising evidence that the dynamic changes in the gut microorganism can influence physiology and behavior of brain. Dysbiosis or dysbacteriosis is a condition of microbial imbalance inside the intestinal microbiome. It has been associated with disorders of intestinal and extra‐intestinal such as inflammatory bowel disease and other multiple diseases like
Gut Microbiota-Brain Interaction with Special Reference to Alzheimer’s Disease Read More »
Two hallmarks of Parkinson’s disease (PD) are the widespread deposition of misfolded alpha-synuclein (αSyn) protein in the nervous system and loss of substantia nigra dopamine neurons. Recent research has suggested that αSyn aggregates in the enteric nervous system (ENS) lead to prodromal gastrointestinal (GI) symptoms such as constipation in PD, then propagating to the brain stem and eventually triggering neurodegeneration and
The gut-brain axis (GBA) refers to the bi-directional communication thatoccurs between the gut and the brain. Recently, studies have highlightedthe important role of nutrition in modulating the GBA. We will delve into thisexciting area of research and understand how certain diets and foods maybe linked to mood and mental health. Our understanding of the gut-brain
THE GUT-BRAIN AXIS: THE ROLE OF NUTRITION Read More »
The gut microbiota is the set of microorganisms present in the gut, and it is connected to the central nervous system via the gut-brain axis. Despite there is not a definitive description of the eubiotic microbiota architecture, numerous studies have demonstrated its involvement in human behaviour and its relationship with several pathologies. This is a systematic review about the association between dysbiosis on
Chicoric acid (CA), a polyphenolic acid obtained from chicory and purple coneflower (Echinacea purpurea), has been regarded as nutraceutical to combat inflammation, virus and obesity. Parkinson’s Disease (PD) is a common neurodegenerative disorder, and microbiota-gut-brain axis might be the potential mechanism in the pathogenesis and development of PD. The results here demonstrated that oral pretreatments
The gut is connected to the CNS by immunological mediators, lymphocytes, neurotransmitters, microbes and microbial metabolites. A mounting body of evidence indicates that the microbiome exerts significant effects on immune cells and CNS cells. These effects frequently result in the suppression or exacerbation of inflammatory responses, the latter of which can lead to severe tissue
Regulation of common neurological disorders by gut microbial metabolites Read More »
The gut microbiota has gained importance through the years due to its significant influences on the maintenance of human health. A wide variety of microorganisms shape this gut microbiota, which preserves health with the modulation of the immune system, enhancement of the nutrients absorption, or the protection against pathogens’ colonization. The disruption of this microenvironment
The role of probiotics in nutritional health: probiotics as nutribiotics Read More »
Nausea, heartburn, indigestion, constipation, andstomach pain are all kinds of gastrointestinal problems we have faced before. They are easy to dismissas merely an upset stomach, but this mentality couldbuild up and ultimately be detrimental to mental and physicalhealth. Improperly caring for the digestive system can lead toextensive intestinal health issues. The microbiome is a collectionof
The Undeniable Link Between the Brain and Gut Read More »
Our results suggest that vagotomy has protective effects onnigrostriatal dopaminergic degeneration and disease progression insubsequent Parkinson’s disease, but may be unfavorable for cognitiveperformance. The neuroprotective effect of vagotomy could be largelymediated by blocking the spread of α-synuclein from the gut to the brain,and the modulation of inflammatory response might also contribute tosome extent. CLICK TO
Effect of vagotomy on modulation of dopaminergic neurons in Parkinson’s disease Read More »