Gut-Brain axis

$9M Grant Funds Study of Gut-Brain Connection in Parkinson’s Disease

A-Synuclein, Gut Dysbiosis, Gut-Brain axis, Symptoms / Diagnosis, Vagal Nerve /

Dr. Michael Kaplitt, a professor of neurological surgery at Weill Cornell Medicine and a longtime leader in developing cutting-edge surgical therapies for movement disorders, leads a team that has been awarded a three-year, $8.9 million grant from the Aligning Science Across Parkinson’s (ASAP) initiative. The grant will fund an ambitious and innovative multi-institutional collaborative effort to study […]

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MISFOLDED α-SYN – FROM RELEASE AND UPTAKE TO CONTAGION OF ADJACENT CELL, ANY LINKS WITH GUT?

A-Synuclein, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

Alpha-synuclein(α-Syn) is an intracellular protein which is constantly synthesized and degraded underphysiological conditions. Abnormal aggregation of this protein within neuron is associated with severalneurodegenerative disorders, including Parkinson’s disease. Although the exact mechanism of initiation ofaggregation and misfolding pathway of a-Syn is yet to be discovered; it’s mechanism of spreading throughinterconnected neuronal networks has taken acompelling

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What Substance P might tell us about the Prognosis and Mechanism of Parkinson’s Disease?

A-Synuclein, Gut-Brain axis, Olfactory, Parkinson's Disease, Vagal Nerve /

The neuropeptide substance P (SP) plays an important role in neurodegenerative disorders, among which Parkinson’s disease (PD). In the present work we have reviewed the involvement of SP and its preferred receptor (NK1-R) in motor and non-motor PD symptoms, in both PD animal models and patients. Despite PD is primarily a motor disorder, non-motor abnormalities,

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Gut Microbiome and Alzheimer’s Disease

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The lack of an effective treatment for Alzheimer’s disease (AD) stems primarily from incomplete understanding of AD’s causes. A rapidly growing number of scientific reports highlight important roles played by peripheral infections and intestinal bacterial flora in pathological and physiological functions involving the microbiome-intestine-brain axis. The microbiome controls basic aspects of the central nervous system

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Investigating Casual Associations among Gut Microbiota, Metabolites and Neurodegenerative Diseases: A Mendelian Randomization Study

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Parkinson's Disease /

Our study firstly applied a two-sample MR approach to detect causal relationships among gut microbiota, gut metabolites and the risk of AD, PD and ALS, andwe revealed several causal relationships. These findings may provide new targets for treatment of these neurodegenerative diseases, and may offer valuableinsights for further researches on the underlying mechanisms. In summary,

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A New Kind of Pathogen – The prion-like pathology of amyloid fibrils in Parkinson’s disease

A-Synuclein, Dementia - Lewy Bodies, Gut-Brain axis, Olfactory, Parkinson's Disease, Pre-PD, Vagal Nerve /

This chapter contrasts the prion-like behavior of alphasynuclein in Parkinson’s disease with other prion diseases.In prion diseases, the infectious, amyloid form of theprotein induces the corresponding normally folded proteinto assume the toxic fold, spreading the disease and slowlydestroying the brains of infected patients. Lewy pathologyin Parkinson’s disease appears to spread in a mannersimilar to that

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The effect of oral butyrate administration on the release of serotonin and dopamine in the gastrointestinal trac

Butyrate, Gut Microbiota, Gut-Brain axis /

The microbiota-gut-brain axis is a modern concept with wide and physiologically important effects.The aim of the study was to investigate if an orally given short chain fatty acid (SCFA), butyrate,stimulates the formation and release of serotonin and dopamine in an in vivo rat model. The effect ofbutyrate was investigated in the entire gastrointestinal tract since

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Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation

Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis /

The gut microbiota provides potential therapeutic targets that can be regulated as new interventions for neurodegenerative diseases. In this review, we discuss genetic and environmental risk factors for neurodegenerative diseases, summarize the communication among the components of the microbiota-gut-brain axis, and discuss the treatment strategy of fecal microbiota transplantation (FMT). FMT is a promising treatment

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Gut brain axis: an insight into microbiota role in Parkinson’s disease

Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The gut-brain axis is a two-way communication system, which explains how through the vagus nerve, the gut microbiota can affect the central nervous system (CNS), including brain functions related to the ENS, as well as how CNS can alter various gut secretions and immune responses. As a result, this dysbiosis or alteration in gut microbiota

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Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

Butyrate, Gut Dysbiosis, Gut-Brain axis, Metabolites, Mitochondria, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Psychobiotics—live microorganisms with potential mental health benefits, which can modulate the microbiota-gut-brain-axis via immune, humoral, neural, and metabolic pathways—are emerging as novel therapeutic options for the effective treatment of psychiatric disorders Recently, microbiome studies have identified numerous putative psychobiotic strains, of which short-chain fatty acids (SCFAs) producing bacteria have attracted special attention from neurobiologists. Recent

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