Gut-Brain axis

Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson’s Disease Synucleinopathy

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Herbs & Spices, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The cross-reactivity and sequence homology between α-synuclein and frequently consumed foods, reinforces the autoimmune aspect of Parkinson’s disease. It is hypothesized that luminal food peptides that share cross-reactive epitopes with human α-synuclein and have molecular similarity with brain antigens are involved in the synucleinopathy. The findings deserve further confirmation by extensive research. CLICK TO REVIEW

Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson’s Disease Synucleinopathy Read More »

The gut microbiome: implications for neurogenesis and neurological diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Short Chain Fatty Acids /

The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation of this disease. Microbiota analysis has revealed increased Enterobacteria and decreased Prevotella strains in patients with PD (Scheperjans et al., 2015). Another clinical study found that, compared with healthy controls, patients with PD exhibited decreases in a range of

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Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats

Butyrate, Gut Dysbiosis, Gut-Brain axis, Short Chain Fatty Acids /

Short chain fatty acids readily crosses the gut-blood and blood–brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous system may play a role in the regulation of intestinal functions. Colonic permeability and visceral sensation was evaluated in rats. Septic

Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats Read More »

The microbiota-gut-brain axis and Alzheimer disease. From dysbiosis to neurodegeneration: focus on the central nervous system glial cells

Gut Dysbiosis, Gut-Brain axis /

Much evidence has accumulated over the past decade in favor of a significant association between dysbiosis, neuroinflammation and neurodegeneration. Presently, the pathogenetic mechanisms triggered by molecules produced by the altered microbiota, also responsible for the onset and evolution of Alzheimer Disease will be described. Our attention will be focused on the role of astrocytes and

The microbiota-gut-brain axis and Alzheimer disease. From dysbiosis to neurodegeneration: focus on the central nervous system glial cells Read More »

Does modern research validate the ancient wisdom of gut flora and brain connection?

Gut-Brain axis /

Both animal and human studies evaluating the role of gut dysbiosis on various neurological and neurosurgical diseases, published in peer-reviewed journals, were reviewed. Current studies do not provide conclusive evidence of a direct origin of CNS disorders from gut dysbiosis, but a possible modulatory role of gut microbiota in certain neurological disorders has been implicated.

Does modern research validate the ancient wisdom of gut flora and brain connection? Read More »

Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis /

Parkinson’s disease (PD) is a complicated neurodegenerative disease attributed to multifactorial changes. However, its pathological mechanism remains undetermined. Accumulating evidence has revealed the emerging functions of gut microbiota and microbial metabolites, which can affect both the enteric nervous system and the central nervous system via the microbiota-gut-brain axis. Accordingly, intestinal dysbiosis might be closely associated

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The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

A-Synuclein, Gut-Brain axis, Parkinson's Disease /

Consequently, the initial α-synuclein pathology inside the CNS is more symmetric, which promotes more symmetric propagation in the brainstem, leading to more symmetric dopaminergic degeneration and less motor asymmetry. At diagnosis, body-first patients already have a larger, more symmetric burden of α-synuclein pathology, which in turn promotes faster disease progression and accelerated cognitive decline. The

The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline Read More »

Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics

Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Thus, BEVs may be both a cause of and solution to neuropathological conditions. In this review, current knowledge of the physiological roles of BEVs as well as state of the art pertaining to the development of therapeutic BEVs in the context of the microbiome-gut-brain axis are summarized. CLICK TO REVIEW

Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics Read More »

The role of gut dysbiosis in Parkinson’s disease: mechanistic insights andtherapeutic options

A-Synuclein, Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

We highlight recent discoveries and alterations of the gut microbiota in Parkinson’s disease, and highlight current mechanistic insights on the microbiota-gut-brain axis in disease pathophysiology. We discuss the interactions between production and transmission of α-synuclein and gut inflammation and neuroinflammation. In addition, we also draw attention to diet modification, use of probiotics and prebiotics and

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The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy

Autophagy, Gut Dysbiosis, Gut-Brain axis, Vagal Nerve /

Hence, this review will mainly focus on analysing the basic components of the gut that might be responsible for aggravating lewy pathology, the mediator(s) responsible for transmission of PD pathology from gut to brain and the important role of trehalose in ameliorating gut dysbiosis related PD complications that would eventually pave the way for therapeutic

The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy Read More »