Gut Dysbiosis

Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery

A-Synuclein, Gut Dysbiosis, Mitochondria /

Parkinson’s Disease (PD) is a highly prevalent neurodegenerative disease among olderadults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons of thesubstantia nigra pars compacta and the widespread accumulation of misfolded intracellularα-synuclein (α-syn). Genetic mutations and post-translational modifications, such as α-syn phosphorylation, have been identified among the multiple factors supporting α-syn accrual […]

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Gut Microbiome and Alzheimer’s Disease

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The lack of an effective treatment for Alzheimer’s disease (AD) stems primarily from incomplete understanding of AD’s causes. A rapidly growing number of scientific reports highlight important roles played by peripheral infections and intestinal bacterial flora in pathological and physiological functions involving the microbiome-intestine-brain axis. The microbiome controls basic aspects of the central nervous system

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Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

Butyrate, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about whether and how gut microbiota alterations are causally associated with CRC development. Here we show that 12 faecal bacterial taxa are enriched in CRC patients in two independent cohort studies. Among them, 2 Porphyromonas species

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Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Gut Dysbiosis /

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut microbiota and the brain via immune, circulatory and neural pathways, termed the Gut-Brain Axis (GBA). Alterations in gut microbiota composition, such as seen with an

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Investigating Casual Associations among Gut Microbiota, Metabolites and Neurodegenerative Diseases: A Mendelian Randomization Study

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Parkinson's Disease /

Our study firstly applied a two-sample MR approach to detect causal relationships among gut microbiota, gut metabolites and the risk of AD, PD and ALS, andwe revealed several causal relationships. These findings may provide new targets for treatment of these neurodegenerative diseases, and may offer valuableinsights for further researches on the underlying mechanisms. In summary,

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The effects of coffee consumption and antibiotic use on gut microbial community structure of Parkinson’s disease patients

Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is a complex brain disorder involving a multitude ofcontributing factors ranging from environmental to genetic. Interestingly, it has been foundthat the gut microbial community is altered in PD patients when compared to that of non-PDindividuals. However, the factors contributing to altered gut microbiota remain largelyunexplored. As such, the first objective of our

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Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut—A Pilot Study

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Vitamins / Supplements / Nutraceuticals /

Daily supplementation of high-dose vitamin C led to an increase in the relative abundances of Lachnospiraceae (p < 0.05), whereas decreases were observed for Bacteroidetes (p < 0.01), Enterococci (p < 0.01) and Gemmiger formicilis (p < 0.05). In addition, trends for bacterial shifts were observed for Blautia (increase) and Streptococcus thermophilus (decrease). High-dose vitamin

Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut—A Pilot Study Read More »

Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation

Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis /

The gut microbiota provides potential therapeutic targets that can be regulated as new interventions for neurodegenerative diseases. In this review, we discuss genetic and environmental risk factors for neurodegenerative diseases, summarize the communication among the components of the microbiota-gut-brain axis, and discuss the treatment strategy of fecal microbiota transplantation (FMT). FMT is a promising treatment

Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation Read More »

Gut brain axis: an insight into microbiota role in Parkinson’s disease

Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The gut-brain axis is a two-way communication system, which explains how through the vagus nerve, the gut microbiota can affect the central nervous system (CNS), including brain functions related to the ENS, as well as how CNS can alter various gut secretions and immune responses. As a result, this dysbiosis or alteration in gut microbiota

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Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia

Gut Dysbiosis /

Here, we show that a carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota. Depleting the microbiome reduces CI, whereas transplantation of the risk-associated microbiome or monocolonization with Bilophila wadsworthia confers CI in mice fed a standard diet. B. wadsworthia and the risk-associated microbiome disrupt hippocampal synaptic plasticity, neurogenesis, and gene expression. The CI is associated with

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