Gut Dysbiosis

Oral Dysbiosis and Alzheimer’s Disease Risk

Dementia - Lewy Bodies, Gut Dysbiosis, Periodontitis /

The oral microbiome is implicated in many systemic illnesses such as cardiovascular disease, metabolic syndrome, respiratory infections, and cognitive decline, with the common link between them being inflammation.1-4 A connection between oral health, inflammation, and neurodegenerative conditions such as Alzheimer’s disease (AD) has long been speculated, and recent findings have suggested that chronic bacterial infections from […]

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The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease

ENS, Gut Dysbiosis /

The second part ofthe study provides evidence on how these very same neurons are altered during Parkinson’s disease.In fact, although being defined as a movement disorder, Parkinson’s disease features a number ofdegenerative alterations, which often anticipate motor symptoms. Among these, the GI tract is ofteninvolved, and for this reason, it is important to assess its

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IMPACT OF THE SHORT – CHAIN FATTY ACIDS ON THE MICROBIOTA – GUT – BRAIN AXIS

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

Studies show that short – chain fatty acids have differenteffects by increasing or decreasing the quantity of certain molecules such as GLP-1,peptide YY, insulin, glucagon, ghrelin, leptin and serotonin while they also have animpact on the nervous system. Also is needed to emphasize its role in certainneurological diseases such as Parkinson, autism spectrum disorder and

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Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

However, there is limited success in restoring healthy microbial biodiversity in AD and PD patients with general probiotics interventions and fecal microbial therapies. Fortunately, the gut microflora is susceptible to long-term extrinsic influences such as lifestyle and dietary choices, providing opportunities for treatment through comparatively individual-specific control of human behavior. In this review, weexamine the

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Clinical and Pre-Clinical Evidence for Enteric α-Synuclein Involvement in Parkinson’s Disease

A-Synuclein, Gut Dysbiosis, Gut Permeability / Leaky Gut, Vagal Nerve /

While commonly attributed to neuronal death in SNpc, postmortem studies have shown α-syn immunoreactivity and LB pathology inthe peripheral, central, and enteric nervous system (ENS).While the etiology of misfolded α-syn is unknown, variousgut microbiota and substrates are associated with α-syndysfunction. Gastrointestinal (GI) dysfunction, a commonfeature in the prodromal phase of PD patients, and histological evidence

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Modulation of Neuroinflammation by the Gut Microbiota in Prion and Prion-Like Diseases

Gut Dysbiosis, Gut Microbiota, Mitochondria, Parkinson's Disease, Pre-PD /

One fundamental component of systemic homeostasis is the gut microbiota, which communicates withthe CNS via microbial metabolite production, the peripheral nervous system, and regulation oftryptophan metabolism. Over the past 10–15 years, research focused on the microbiota–gut–brainaxis has culminated in the discovery that dysbiosis, or an imbalance between commensal andpathogenic gut bacteria, can promote CNS pathologies.

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Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson’s disease

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

In general, the relative proportions of the main bacterial phyla in the microbiotas of PD patients differed from those of healthy subjects, with levels of Firmicutes raised and levels of Bacteroidetes reduced. Dosing with probiotic resulted in a change in bacterial composition in the microbiotas over a 48 h period. Several other indicators of gut health changed upon dosing with

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Serum and Fecal Markers of Intestinal Inflammation and Intestinal Barrier Permeability Are Elevated in Parkinson’s Disease

A-Synuclein, Fecal Transplants (FMT), Gut Dysbiosis, Olfactory, Vagal Nerve, Zonulin /

Parkinson’s disease (PD) is characterized by alpha-synuclein misfolding with subsequent intraneuronal amyloid formation and accumulation, low grade neuroinflammatory changes, and selective neurodegeneration. Available evidence suggests that thepathology usually begins in the gut and olfactory mucosa, spreading to the brain via the vagus and olfactory nerves, by a prion-like mechanism. A causal relationship has not been

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Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

Biomarkers, Gut Dysbiosis, Gut Microbiota, Hydrogen, Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are

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Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

Butyrate, Gut Dysbiosis, Gut-Brain axis, Metabolites, Mitochondria, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Psychobiotics—live microorganisms with potential mental health benefits, which can modulate the microbiota-gut-brain-axis via immune, humoral, neural, and metabolic pathways—are emerging as novel therapeutic options for the effective treatment of psychiatric disorders Recently, microbiome studies have identified numerous putative psychobiotic strains, of which short-chain fatty acids (SCFAs) producing bacteria have attracted special attention from neurobiologists. Recent

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