Gut Dysbiosis

Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson’s Disease Synucleinopathy

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Herbs & Spices, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The cross-reactivity and sequence homology between α-synuclein and frequently consumed foods, reinforces the autoimmune aspect of Parkinson’s disease. It is hypothesized that luminal food peptides that share cross-reactive epitopes with human α-synuclein and have molecular similarity with brain antigens are involved in the synucleinopathy. The findings deserve further confirmation by extensive research. CLICK TO REVIEW

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Exploration of Host Health Benefits by a Defined Consortium of Butyrate-Producing Human Gut Bacteria In Gnotobiotic Mouse Model

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Mitochondria, Short Chain Fatty Acids /

Aberrant gut microbiota composition is found to be associated with several human diseases such as inflammatory bowel diseases (IBD). Reduction in butyrate producing bacteria is one of the characteristic features of such dysbiotic bacterial community in the gut. Modulation of gut microbiota to bring the dysbiotic state back to normal healthy state is a promising

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Identification and Characterization of Butyrate-Producing Species in the Human Gut Microbiome

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria, Short Chain Fatty Acids /

Inflammatory Bowel Diseases (IBD) including ulcerative colitis, Crohn’s disease, and indeterminate colitis are increasingly common conditions that places a high physical and financial burden on individuals and global healthcare systems. Though treatments exist for these conditions, their unpredictable nature and causation make them difficult to manage consistently across the variety of IBD patients. Additionally, many

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Increased Host Energy Metabolism in the Proximal Colon-Microbiota Interface Elevates Blood Pressure

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

Collectively our data reported here is the first to provide evidence for a direct relationship between host energy metabolism at the proximal gut-microbiota interface and BP regulation. Further, our studies suggest that butyrate, which is a predominant colonic energy metabolite, contributes to the mechanism governing this relationship between energy metabolism in the proximal colon with

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Commensal Bacteria Derived Metabolite Butyrate Restores the Epithelial Mitochondrial Network Disrupted by the Crohn’s Disease-Associated Pathobiont Adherent Invasive E-coli Infection

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria /

These data indicate that pathogen disruption of the epithelial mitochondrial network is a component of IBD that could identify novel targets to control enteric inflammation. These data underscore the complex bacterial-epithelium interaction: commensal organisms may preserve the mitochondrial network in the face of challenge from pathogens that seek to disrupt mitochondrial form and function. CLICK

Commensal Bacteria Derived Metabolite Butyrate Restores the Epithelial Mitochondrial Network Disrupted by the Crohn’s Disease-Associated Pathobiont Adherent Invasive E-coli Infection Read More »

Butyrate administration strengthens the intestinal epithelium and improves intestinal dysbiosis in a cholestasis fibrosis model

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria /

Intestinal dysfunction in cirrhosis patients is linked to death by bacterial infections. Currently, there is no effective therapy for this complication. This study aims to evaluate butyrate, a novel postbiotic, on the intestinal inflammatory response, tight junction proteins, and the microbiota in the cholestasis model. Butyrate is effective in regulating the inflammatory response, tight junction

Butyrate administration strengthens the intestinal epithelium and improves intestinal dysbiosis in a cholestasis fibrosis model Read More »

Disease Modifying Potential of Functional Foods for Neurodegenerative Disorders: Status Update on Regulatory Compliance

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

Progressive loss of functional neurons is typically characterized as neurodegeneration. This is particularly pronounced during aging and results in debilitating conditions such as Parkinson’s disease and Alzheimer’s disease. Symptoms appear typically after 70–80% neuronal loss, resulting in irreversible damage. Several drugs have been clinically approved but they only alleviate symptoms and additionally lead to undesirable

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The gut microbiome: implications for neurogenesis and neurological diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Short Chain Fatty Acids /

The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation of this disease. Microbiota analysis has revealed increased Enterobacteria and decreased Prevotella strains in patients with PD (Scheperjans et al., 2015). Another clinical study found that, compared with healthy controls, patients with PD exhibited decreases in a range of

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Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study

Biomarkers, Gut Dysbiosis, Gut Permeability / Leaky Gut, Lipopolysaccharides (LPS), Parkinson's Disease, Pre-PD, Zonulin /

Biomarkers that link a leaky gut and subsequent bacterial translocation to metabolic health were identified in this study. Especially zonulin may aid in monitoring a leaky gut and detecting individuals at risk for developing chronic metabolic diseases. CLICK TO REVIEW

Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study Read More »

Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate

Butyrate, Gut Dysbiosis, Hydrogen /

Further experiments demonstrated that the beneficial effect of butyrate depended on the bacteria that colonized the gut and that this protective effect required SKN-1/Nrf2 and DAF-16/FOXO transcription factors. We also found that bacteria-derived protein aggregates contribute to the observed disruption of host proteostasis. Together, these results reveal the significance of enteric infection and gut dysbiosis

Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate Read More »