Gut Dysbiosis

Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Biomarkers, Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Metabolites, Pre-PD, Short Chain Fatty Acids /

We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as […]

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Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders

Gut Dysbiosis, Gut Microbiota, Vagal Nerve /

The microbiota–gut–brain axis (MGBA) is a bidirectional signaling pathway mediating the interaction of the microbiota, the intestine, and the central nervous system. While the MGBA plays a pivotal role in normal development and physiology of the nervous and gastrointestinal system of the host, its dysfunction has been strongly implicated in neurological disorders, where intestinal dysbiosis

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Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Lipopolysaccharides (LPS), Probiotics, Prebiotics and Symbiotics /

The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest that the GM can influence the health of the host, and several factors can modify the GM composition, such as diet, drug intake, lifestyle, and geographical locations. Gut

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Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota

Gut Dysbiosis, Gut Microbiota, Therapies /

The L-dopa produced by the intestinal bacteria enters the brain through the circulation and is transformed to dopamine. To verify the gut–brain dialog activated by BBR’s effect, Enterococcus faecalis or Enterococcus faecium was transplanted into Parkinson’s disease (PD) mice. The bacteria significantly increased brain dopamine and ameliorated PD manifestation in mice; additionally, combination of BBR with bacteria showed better therapeutic

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Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Diet and Exercise, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Probiotics, Prebiotics and Symbiotics /

Gut dysbiosis can affect brain immune homeostasis through the microbiota–gut–brain axis and can play a key role in the pathogenesis of neurodegenerative diseases, including dementia and Alzheimer’s disease (AD). The relationship between gut dysbiosis and AD is still elusive, but emerging evidence suggests that it can enhance the secretion of lipopolysaccharides and amyloids that may

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Gastrointestinal biopsies and amyotrophic lateral sclerosis – results from a cohort study of 1.1 million individuals

Gut Dysbiosis, Gut Microbiota /

Individuals with a GI biopsy result of normal mucosa—representing potentially a distinct type of GI dysfunction—had a higher future risk of ALS. No association was however noted for a GI biopsy result of non-specific inflammation. Further studies are needed to validate this finding and to understand the underlying reasons for the contrasting result pattern. CLICK

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Prophylactic Role of Aloe Components, Butyrate Fermented, Micrnas, and Hyaluronan on Alzheimer’s Disease, Parkinson’s Disease, and Osteoarthritis in Knee Joints

Butyrate, Gut Dysbiosis, Gut-Brain axis, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Host microbial cross talk is essential to maintain intestinal homeostasis. However, maladaptation of the response through microbial dysbiosis or defective host defense toward invasive intestinal microbial results in chronic inflammation and the mild cognitive impairment. The role of active constituents from Aloe species, fermented butyrate, and micRNAs on Alzheimer’s disease, and Parkinson’s disease is discussed

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Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury

Fecal Transplants (FMT), Gut Dysbiosis /

In conclusion, the current study showed that TBI can induce the gut microbiome dysbiosis and that FMT can rescue gut microbiota dysbiosis, relieve the neurological deficits, and exert an antioxidation effect through decreasing TBI-induced TMAO and increasing the antioxidant enzyme MsrA expression in the hippocampus. CLICK TO REVIEW

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Spectrum of Non-Motor Symptoms in Parkinson’s Disease

A-Synuclein, Biomarkers, Gut Dysbiosis, iRBD, Olfactory, Pre-PD /

Parkinson’s disease is predominantly classified as a movement disorder. Beyond the textbook definition of rigidity, tremors, and bradykinesia, Parkinson’s disease encompasses an entire entity of non-motor symptom complexes that can precede the motor features by many years. Despite their significant clinical importance, the awareness of non-motor symptoms is quite negligible. Sleep disorders, gastrointestinal dysfunction, olfactory

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Advances of Mechanisms-Related Metabolomics in Parkinson’s Disease

Biomarkers, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Mitochondria, Pre-PD, Short Chain Fatty Acids /

In this review, we briefly summarize recent findings and analyze the application of molecular metabolomics in familial and sporadic PD from genetic mutations, mitochondrial dysfunction, and dysbacteriosis. We also review metabolic biomarkers to assess the functional stage and improve therapeutic strategies to postpone or hinder the disease progression. CLICK TO REVIEW

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