Here, we summarize the types and prevalence of subjective gastrointestinal symptoms and objective dysfunction in PD. The potential importance of the gastrointestinal tract in the etiopathogenesis of PD is briefly discussed. CLICK TO REVIEW
Gastrointestinal Dysfunction in Parkinson’s Disease Read More »
In conclusion, the present study demonstrates the power of using multi-omics molecular profiling to reveal changes in the gut microbiome and serum biochemistry following exposure to chemical pollutants that would otherwise be missed using more standard, less comprehensive analytical methods. Employing this approach allowed us to identify glyphosate effects on the rat gut microbiota, namely
The most significant changes within the Parkinson’s disease group highlighted a reduction in bacterial taxa, which are linked to anti-inflammatory/neu-roprotective effects, particularly in the Lachnospiraceae family and key members,such as Butyrivibrio, Pseudobutyrivibrio, Coprococcus, andBlautia. The direct evalua-tion of fecal metabolites revealed changes in several classes of metabolites. Changeswere seen in lipids (linoleic acid, oleic acid,
Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease Read More »
Gut dysbacteriosis is closely related to various intestinal and extraintestinal diseases. Fecal microbiota transplantation (FMT) is a biological therapy that entails transferring the gut microbiota from healthy individuals to patients in order to reconstruct the intestinal microflora in the latter. It has been proved to be an effective treatment for recurrent Clostridium difficile infection. Studies show that
Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain Read More »
The impact of diet, particularly fiber, on the human microbiome influences broad classes of metabolites that may modify health. CLICK FOR REVIEW
Role of dietary fiber in the recovery of the human gut microbiome and its metabolome Read More »
The 16S KEGG function prediction suggested that Parkinson disease, retinol metabolism, and arachidonic acid metabolism could explain the biological function of different gut microbiome. Furthermore, cytokines in the serum showed a correlation with the abundance of Pseudobutyrivibrio in CFC. Conclusion. AMT could change the composition of gut microbiome which is associated with cytokines in CFC patients. CLICK TO
If therapeutic manipulation of gut microbiota proves effective to treat some pathogenic aspects of PD, an important inquiry would be at which point of the disease evolution these therapies should be implemented. It is accepted that microbiota conformation is shaped early in life with relative minor changes later on. However, patients with rapid eye movement-sleep
Gut microbiota: a potential therapeutic target for Parkinson’s disease Read More »
More attention than ever is being put on your gut health, and understandably so, considering a significant proportion of your immune system resides in your gastrointestinal tract.1 As such, optimizing your gut microbiome is a worthwhile pursuit that will have far-reaching effects on your physical health and emotional well-being. Mounting scientific evidence also continues to suggest
How Your Gut Health Impacts Your Disease Risk Read More »
The microbiome lies at the forefront of scientific research, as researchers work to uncover its mysterious influence on human development and disease. Though the clinical applications of microbiome manipulation are currentlylimited, the significance of dysbiosis in the etiology of a wide array of diseases indicates the significance of this research and highlights the need for
Managing the Microbiome – How the Gut Influences Development and Disease Read More »