Gut Dysbiosis

Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases

ENS, Gut Dysbiosis, Gut Microbiota /

Emerging evidence suggests that both disruption of circadian rhythms and gut dysbiosis are closely related to aging-associated neurodegenerative diseases. Over the last decade, the microbiota-gut-brain axis has been an emerging field and revolutionized studies in pathology, diagnosis, and treatment of neurological disorders. Crosstalk between the brain and gut microbiota can be accomplished via the endocrine, […]

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Gut–Brain Cross Talk: Microbiome
and Micronutrients

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

A good diet may deliver micronutrients such as vitamins A, B6, B12, C,and D and minerals such as iron, copper, zinc, and selenium that have beenimplicated to have key roles for supporting immunity with reducing host infections.Most studies have shown that once the subject was infected, the immune system willbe enhanced, which will require high

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and Micronutrients Read More »

Inulin fructans in diet: Role in gut homeostasis, immunity, health outcomes and potential therapeutics

Diet and Exercise, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Inulin consumption in both humans and animal models is recognized for its prebiotic action with the most consistent change that lies in enhancing the growth and functionality of Bifidobacterium bacteria, as well as its effect on host gene expression and metabolism. Further, inulin-type fructans are utilized in the colon by bacterial fermentation to yield short-chain fatty acids (SCFAs), which play

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Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis?

Enviromental, Glyphosate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Environmental exposure to glyphosate and glyphosate-based herbicides has the potential to negatively influence neurodevelopment and behavior across generations indirectly through the gut-brain-microbiome axis. Potential mechanisms by which glyphosate may elicit these effects are through the disruption of the normally symbiotic relationship of the host and the gut microbiome. Given glyphosate can kill commensal members of

Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis? Read More »

Impact of environmental toxicants exposure on gut-brain axis in Parkinson disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson disease (PD) is a major public health challenge as many of the current drugs used in its management provide symptomatic relieve without preventing the underlying cause of the neurodegeneration. Similarly, the non-motor complications of PD, especially the gastrointestinal tract (GIT) disturbance increases the disease burden on both the PD patient and caregivers. Different theories

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Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate

Butyrate, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Metabolites, Short Chain Fatty Acids /

Our data indicate a cause–effect relationship between gut microbiota and PSCI for the first time, which is likely mediated by inflammation-regulating metabolites including LPS and butyrate. CLICK TO REVIEW

Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate Read More »

Preventing Bacterial Translocation in Patients with Leaky Gut
Syndrome: Nutrition and Pharmacological Treatment Options

Gut Dysbiosis, Gut Permeability / Leaky Gut, Probiotics, Prebiotics and Symbiotics /

: Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability.Since the intestinal barrier is one of the essential components maintaining homeostasis along thegastrointestinal tract, loss of its integrity due to changes in bacterial composition, decreased expression levels of tight junction proteins, and increased concentration of pro-inflammatory cytokinesmay lead to intestinal hyperpermeability followed by

Preventing Bacterial Translocation in Patients with Leaky Gut
Syndrome: Nutrition and Pharmacological Treatment Options Read More »

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights

A-Synuclein, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss andα-synuclein (α-syn) aggregation. With the acceleration of population aging process, the incidence of PD is expected toincrease, putting a heavy burden on the whole society. Recent studies have found the alterations of gut microbiota (GM) inPD patients and the clinical relevance of

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights Read More »

The potential applications of traditional Chinese medicine in Parkinson’s disease: A new opportunity

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) presents a common challenge for people all over the world and has become a major research hotspot due to the large population affected by the illness and the difficulty of clinical treatment. The prevalence of PD is increasing every year, the pathogenesis is complex, and the current treatment is ineffective. Therefore, it has

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The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential

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