Gut Dysbiosis

Effect of fermented foods on some neurological diseases, microbiota, behaviors: mini review

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

Fermented foods are among the traditional foods consumed for centuries. In recent years, awareness of fermented foods has been increasing due to their positive health benefits. Fermented foods contain beneficial microorganisms. Fermented foods, such as kefir, kimchi, sauerkraut, and yoghurt, contain Lactic acid bacteria (LAB), such as Lactobacilli, Bifidobacteria, and their primary metabolites (lactic acid). Although studies on […]

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Dietary manipulation of the gut microbiome in inflammatory bowel disease
patients: Pilot study

Diet and Exercise, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinalmicrobiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linkedto inflammation. Here, we aim to define the impact of specific foods on bacterial species commonlydepleted in patients with IBD to better inform dietary treatment. We performed a single-arm, prepost

Dietary manipulation of the gut microbiome in inflammatory bowel disease
patients: Pilot study Read More »

Short-Chain Fatty Acids Modulate Healthy Gut Microbiota Composition and Functional Potential

Biomarkers, Butyrate, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

Many studies have focused on the metabolic capacity of human gut microbiota to produce short-chain fatty acids and subsequent effects on host physiology. Given scarce data on how SCFAs produced by gut bacteria participate in cross-feeding to influence community structure and function, we evaluated the potential of SCFAs to modulate human gut microbiota in vitro.

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Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson’s Disease in the Province of Brescia, Italy

A-Synuclein, Diet and Exercise, Gut Dysbiosis, Parkinson's Disease /

Environmental exposures to agrochemicals and nutritional factors may be associated with Parkinson’s Disease (PD). None of the studies to date has examined the combined effects of diet and agricultural chemical exposure together. To address these research gaps, we aimed to assess the association of nutritional factors and agrochemical exposure with the risk of PD. A

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Brain-Gut-Microbiota Axis in Schizophrenia and Parkinson’s
Disease

Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD, Vagal Nerve /

Dopaminergic cells, which use dopamine as a neurotransmitter, arenot as numerous as other brain nerve cells such as serotonergic andGABAergic neurons. However, dopamine neurons project to a varietyof important brain regions to control movement, emotion, the rewardsystem, and the secretion of prolactin. Both schizophrenia andParkinson’s disease are disorders of the dopaminergic neurotransmissions, but schizophrenia has

Brain-Gut-Microbiota Axis in Schizophrenia and Parkinson’s
Disease Read More »

The role of the probiotic Akkermansia muciniphila in brain functions: insights underpinning therapeutic potential

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

The role of Akkermansia muciniphila, one of the most abundant microorganisms of the intestinalmicrobiota, has been studied extensively in metabolic diseases, such as obesity and diabetes. Itis considered a next-generation probiotic microorganism. Although its mechanism of action hasnot been fully elucidated, accumulating evidence indicates the important role of A. muciniphilain brain functions via the gut-brain

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Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases

A-Synuclein, Biomarkers, Butyrate, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Age-dependent protein-conformational diseases (PCDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), or amyotrophic lateral sclerosis (ALS), are characterized by misfolding and aggregation of metastable proteins present within the proteome of the affected individual. Recent evidence supports the notion that bacteria and bacterial products may be affecting the stability of these culprit host proteins and

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Probiotic Bacillus subtilis
Protects against a-Synuclein
Aggregation in C. elegans

A-Synuclein, Butyrate, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits a-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in

Probiotic Bacillus subtilis
Protects against a-Synuclein
Aggregation in C. elegans Read More »

The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Our findings support a mediating role of the gut microbiome in the beneficial effects of the Green-MED diet enriched with Mankai and green tea on cardiometabolic risk factors. CLICK TO REVIEW

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Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options

Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The global incidence of numerous immune-mediated, metabolic, neurodegenerative, and psychiatric diseases is steadily increasing [1,2,3]. The increased morbidity of human populations makes them more vulnerable to additional burdens, including infectious diseases. For example, the mortality rate of diabetics infected with the original variant of the SARS Co-2 virus was about twice that of the general

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