Gut Microbiota

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Ayahuasca, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Uncategorized /

N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of […]

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Good bacteria, oxidative stress and neurological disorders: Possible therapeutical considerations

Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

Although oxidative agents such as free radicals can fight pathogens, an imbalance of oxidants to anti-oxidant activity can lead to harmful effects in our body known as oxidative stress. Various cellular organelles produce oxidative agents as well as anti-oxidants. The main oxidative stressors are classified under the free radical species; reactive oxygen species and reactive

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Metabolites from the Gut Microbiota and the Role in the
Gut-Brain Axis

Butyrate, Gut Microbiota, Gut-Brain axis, Short Chain Fatty Acids /

The gut microbiota is highly capable of biotransformation, exposing the host to a wide varietyof physiologically active compounds. These metabolites participate in signaling between thegastrointestinal tract and the central nervous system and may regulate physiological andpathological processes in the central nervous system. This bidirectional communication cantake place in a variety of ways, including binding to

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Gut-Brain Axis Read More »

Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD /

Growing evidences show that gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD) and the gut-brain axis can be promising target for the development of the therapeutic strategies for PD. Acupuncture has been used to improve brain functions and inflammation in neurological disorders such as PD, and to recover the gastrointestinal dysfunctions in

Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease Read More »

Microbiota in health and diseases

Gut Microbiota, Gut-Brain axis /

The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on thelocalized regions, microbiota can be classified into gut, oral, respiratory, and skin microbiota. The microbial communities are insymbiosis with the host, contributing to homeostasis and regulating immune function. However, microbiota dysbiosis can lead todysregulation of bodily

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Parkinson’s Disease: A Prionopathy?

A-Synuclein, Biomarkers, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis /

The principal pathogenic event in Parkinson’s disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal loss in specific brain regions. Over the last few years, a revolutionary theory has correlated Parkinson’s disease and other neurological disorders with a shared

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Aging Microbiota-Gut-Brain Axis in Stroke Risk
and Outcome

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Stroke /

The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbes and theirhost. Many environmental and host-related factors affect the gut microbiota. Dysbiosis is defined as compositional andfunctional alterations of the gut microbiota that contribute to the pathogenesis, progression and treatment responses todisease. Dysbiosis occurs when perturbations of microbiota composition and function exceed the ability

Aging Microbiota-Gut-Brain Axis in Stroke Risk
and Outcome Read More »

Modulation of gut health using probiotics: the role of probiotic effector molecules

Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Probiotics affect intestinal metabolism and play a crucial role in gut homeostasis. Studies on probiotic effector molecules—bacteriocins, peptidoglycan, teichoic acid, exopolysaccharides, secretory proteins, and short-chain fatty acids—describe their effect on the gut barrier; immune and nervous system; and gut microbiota. However, the detailed mechanism of how the intestinal microbiota changes after the intervention of effector

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Fermented brown rice beverage distinctively modulates the gut microbiota in Okinawans with Metabolic Syndrome: a randomized controlled trial

Butyrate, Diet and Exercise, Fermented Foods, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Accumulating evidence to date suggests that brown rice is superior to white rice in regards to its beneficial impact on a number of risk factors of the metabolic syndrome (MetS). However, little is known about the influence of fermented brown rice beverage on the gut microbiota in humans. We therefore hypothesized that its impact would

Fermented brown rice beverage distinctively modulates the gut microbiota in Okinawans with Metabolic Syndrome: a randomized controlled trial Read More »

Environmental factors shaping the gut microbiome in a Dutch population

Diet and Exercise, Enviromental, Gut Dysbiosis, Gut Microbiota, Metabolites, Parkinson's Disease /

The gut microbiome is associated with diverse diseases1,2,3, but a universal signature of a healthy or unhealthy microbiome has not been identified, and there is a need to understand how genetics, exposome, lifestyle and diet shape the microbiome in health and disease. Here we profiled bacterial composition, function, antibiotic resistance and virulence factors in the

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