Gut Microbiota

Commensal Bacteria Derived Metabolite Butyrate Restores the Epithelial Mitochondrial Network Disrupted by the Crohn’s Disease-Associated Pathobiont Adherent Invasive E-coli Infection

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria /

These data indicate that pathogen disruption of the epithelial mitochondrial network is a component of IBD that could identify novel targets to control enteric inflammation. These data underscore the complex bacterial-epithelium interaction: commensal organisms may preserve the mitochondrial network in the face of challenge from pathogens that seek to disrupt mitochondrial form and function. CLICK […]

Commensal Bacteria Derived Metabolite Butyrate Restores the Epithelial Mitochondrial Network Disrupted by the Crohn’s Disease-Associated Pathobiont Adherent Invasive E-coli Infection Read More »

Butyrate administration strengthens the intestinal epithelium and improves intestinal dysbiosis in a cholestasis fibrosis model

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria /

Intestinal dysfunction in cirrhosis patients is linked to death by bacterial infections. Currently, there is no effective therapy for this complication. This study aims to evaluate butyrate, a novel postbiotic, on the intestinal inflammatory response, tight junction proteins, and the microbiota in the cholestasis model. Butyrate is effective in regulating the inflammatory response, tight junction

Butyrate administration strengthens the intestinal epithelium and improves intestinal dysbiosis in a cholestasis fibrosis model Read More »

Disease Modifying Potential of Functional Foods for Neurodegenerative Disorders: Status Update on Regulatory Compliance

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

Progressive loss of functional neurons is typically characterized as neurodegeneration. This is particularly pronounced during aging and results in debilitating conditions such as Parkinson’s disease and Alzheimer’s disease. Symptoms appear typically after 70–80% neuronal loss, resulting in irreversible damage. Several drugs have been clinically approved but they only alleviate symptoms and additionally lead to undesirable

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The gut microbiome: implications for neurogenesis and neurological diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Short Chain Fatty Acids /

The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation of this disease. Microbiota analysis has revealed increased Enterobacteria and decreased Prevotella strains in patients with PD (Scheperjans et al., 2015). Another clinical study found that, compared with healthy controls, patients with PD exhibited decreases in a range of

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Neurological disorders associated with impaired gut microbiota

Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Proinflammatory mediators such as iNOS, ROS, COX2 and NF-B are released by microglia, resulting in neuroinflammation in Alzheimer’s disease. It is becoming more widely recognized as a symptom of Autism Spectrum Disorder. The establishment of gut-brain psychology is expected to have a significant impact on psychology and related disciplines. CLICK TO REVIEW

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Role of microbiota-derived short-chain fatty acids in nervous system disorders

Butyrate, Gut Microbiota, Short Chain Fatty Acids /

It has been noted remodeling in the gut microbiota metabolites associated with the pathophysiology of several neurological disorders, such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis, stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, and neuromyelitis optica spectrum disorders, among others. This review will discuss the current evidence from the most significant studies dealing with some SCFAs from gut microbial metabolism with selected neurological disorders. CLICK

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Diet-Microbiota-Brain Axis in Alzheimer’s Disease

Gut Microbiota /

A strong association exists between lifestyle factors and AD prevalence wherein unhealthy dietary factors have been linked to neurodegeneration. Specific prudent dietary patterns might help in preventing or delaying AD progression by affecting β-amyloid production and tau processing and regulating AD-associated inflammation, metabolism and oxidative stress, plausibly via modulating gut microbiota. CLICK TO REVIEW

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Gut Microbiome Changes with Osteopathic Treatment of Constipation in Parkinson’s Disease: A Pilot Study

Biomarkers, Constipation, Gut Microbiota /

The gut microbiome shifted among individuals with constipation and PD after four weekly treatments with the OMM-sequence. Changes in the gut microbiome Post-OMM were associated with UPDRS results and constipation measures. Clinical trials and studies to develop the gut microbiome into a validated biomarker for PD are necessary to understand the impact of OMM in

Gut Microbiome Changes with Osteopathic Treatment of Constipation in Parkinson’s Disease: A Pilot Study Read More »

Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis /

Parkinson’s disease (PD) is a complicated neurodegenerative disease attributed to multifactorial changes. However, its pathological mechanism remains undetermined. Accumulating evidence has revealed the emerging functions of gut microbiota and microbial metabolites, which can affect both the enteric nervous system and the central nervous system via the microbiota-gut-brain axis. Accordingly, intestinal dysbiosis might be closely associated

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Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment

Gut Dysbiosis, Gut Microbiota, Metabolites, Mitochondria /

The search for therapeutic targets for Parkinson’s disease (PD) is hindered by the incomplete understanding of the pathophysiology of the disease. Mitochondrial dysfunction is an area with high potential. The neurobiological signaling connections between the gut microbiome and the central nervous system are incompletely understood. Multiple lines of evidence suggest that the gut microbiota participates

Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment Read More »