Gut Microbiota

Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice

Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

As the profound interactions between the gut microbiota and the structure, chemistry, and activity of the brain continue to be discovered, the functional details of how the microbiota-gut-brain-axis works are starting to be resolved. Previous studies have suggested B. longum can cause changes in brain chemistry and activity [20]. Other research has revealed that modifications to expression of […]

Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice Read More »

The role of gut dysbiosis in Parkinson’s disease: mechanistic insights andtherapeutic options

A-Synuclein, Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

We highlight recent discoveries and alterations of the gut microbiota in Parkinson’s disease, and highlight current mechanistic insights on the microbiota-gut-brain axis in disease pathophysiology. We discuss the interactions between production and transmission of α-synuclein and gut inflammation and neuroinflammation. In addition, we also draw attention to diet modification, use of probiotics and prebiotics and

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Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

Diet and Exercise, Gut Microbiota, Short Chain Fatty Acids /

This review specifically highlights the regulatory functions of DF and SCFAs in the immune system with a focus on major innate and adaptive lymphocytes. Current information regarding how SCFAs regulate innate lymphoid cells, T helper cells, cytotoxic T cells, and B cells and how these functions impact immunity, inflammation, and allergic responses are discussed. CLICK

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Dietary restrictions modulate the gut microbiota: Implications for health and disease

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

The data suggest that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression of several diseases such as obesity, diabetes, neurological diseases or inflammatory bowel disease. Finally, the relevance of the findings for clinical practice is evaluated and approaches for future research are proposed. CLICK TO REVIEW

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Microbiota-derived short chain fatty acids modulate microglia and promote Ab plaque deposition

Gut Microbiota, Parkinson's Disease, Short Chain Fatty Acids /

Despite increased microglial recruitment to Ab plaques upon SCFA supplementation, microglia contained less intracellular Ab. Taken together, our results demonstrate that microbiota-derived SCFA are critical mediators along the gut-brain axis which promote Ab deposition likely via modulation of the microglial phenotype. CLICK TO REVIEW

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Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

Butyrate, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

This review provides an overview of the current knowledge of these effects, with specific focus on energy metabolism, intestinal barrier, immune system, and disease activity in IBD. To conclude, more research is needed on the cross-feeding mechanisms in the gut microbiome, as well as on the therapeutic potential of SCFAs on different disease models. Also

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Source of gut microbiota determines oat β-glucan degradation and short chain fatty acid-producing pathway

Butyrate, Gut Microbiota, Short Chain Fatty Acids /

Overall, our data suggested that β-glucan could be completely hydrolyzed by human fecal microbiota but not thoroughly degraded by mice fecal microbiota. The notion shed some light on the effect of gut microbial source on β-glucan degradation, providing new information for the relationship between β-glucan metabolism and gut microbiota. CLICK TO REVIEW

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Comparison of bioactive constituents and effects on gut microbiota by in vitro fermentation between Ophicordyceps sinensis and Cordyceps militaris

Biomarkers, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Herbs & Spices, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

After in vitro digestion and anaerobic fermentation, both O. sinensis and C. militaris could modulate the gut microbiota composition through reducing the ratio of Firmicutes to Bacteroidetes. Moreover, this research demonstrated that O. sinensis had more positive effects on the intestinalhealth compared with C. militaris via decreasing the pH of gut environment, stimulating the production

Comparison of bioactive constituents and effects on gut microbiota by in vitro fermentation between Ophicordyceps sinensis and Cordyceps militaris Read More »

Dietary Influences on the Microbiota–Gut–Brain Axis

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis /

Finally, we should revise our view of the gut microbiota from that of a seething mass of microbes to one of organ-status, on which our health and wellbeing utterly depends. Future guidelines on lifestyle strategies for wellbeing should integrate advice on the optimal establishment and maintenance of a healthy gut microbiota through dietary and other

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The Gut-Brain Axis

Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

The concept of the gut-brain axis (GBA) has existed for more than 3 decades [1]. Gastrointestinal motor and sensory components send messages to the central nervous system (CNS), and the return response to the intestine is the definition of the GBA [2]. Nutrition affects microbiota colonization and gut metabolites, which can influence brain development and

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