Gut Microbiota

Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration

A-Synuclein, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Oral Microbiome, Parkinson's Disease, Pre-PD /

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Creutzfeldt–Jakob disease (CJD) are brain conditions affecting millions of people worldwide. These diseases are associated with the presence of amyloid-β (Aβ), alpha synuclein (α-Syn) and prion protein (PrP) depositions in the brain, respectively, which lead to synaptic disconnection and subsequent progressive neuronal death. Although […]

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From the intestinal mucosal barrier to the enteric neuromuscular compartment: An integrated overview on the morphological changes in Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Non-Motor Symptoms /

Gastrointestinal dysfunctions represent the most common non-motor symptoms in Parkinson’s disease (PD). Ofnote, changes in gut microbiota, impairments of intestinal epithelial barrier (IEB), bowel inflammation and neuroplastic rearrangements of the enteric nervous system (ENS) could be involved in the pathophysiology of theintestinal disturbances in PD. In this context, although several review articles have pooled together

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Potential Role of Akkermansia muciniphila in Parkinson’s Disease and Other Neurological/Autoimmune Diseases

Gut Microbiota, Metabolites, Probiotics, Prebiotics and Symbiotics /

The composition of the gut microbiota, including Akkermansia muciniphila (A. muciniphila), is altered in many neurological diseases and may be involved in the pathophysiological processes of Parkinson’s disease (PD). A. muciniphila, a mucin-degrading bacterium, is a potential next-generation microbe that has anti-inflammatory properties and is responsible for keeping the body healthy. As the role of A. muciniphila in PD has

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Gut Microbiota-Brain Interaction with Special Reference to Alzheimer’s Disease

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Gut microbiota is showing and raising evidence that the dynamic changes in the gut microorganism can influence physiology and behavior of brain. Dysbiosis or dysbacteriosis is a condition of microbial imbalance inside the intestinal microbiome. It has been associated with disorders of intestinal and extra‐intestinal such as inflammatory bowel disease and other multiple diseases like

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The link between the gut microbiota and Parkinson’s Disease: A systematic mechanism review with focus on α-synuclein transport

A-Synuclein, ENS, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD /

Research has suggested a link between the gut microbiota and Parkinson’s Disease (PD), and an early involvement of gastrointestinal dysfunction has been reported in patients. A mechanism review was performed to investigate whether the neurodegenerative cascade begins in the gut; mediated by gut dysbiosis and retrograde transport of α-synuclein. This review provides a summary of

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The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: a systematic review

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

The gut microbiota is the set of microorganisms present in the gut, and it is connected to the central nervous system via the gut-brain axis. Despite there is not a definitive description of the eubiotic microbiota architecture, numerous studies have demonstrated its involvement in human behaviour and its relationship with several pathologies. This is a systematic review about the association between dysbiosis on

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Modeling approaches for probing cross-feeding interactions in the human gut microbiome

Gut Microbiota, Metabolites, Parkinson's Disease, Short Chain Fatty Acids /

Microbial communities perform emergent activities that are essentially different from those carried by their individual members. The gut microbiome and its metabolites have a significant impact on the host, contributing to homeostasis or disease. Food molecules shape this community, being fermented through cross-feeding interactions of metabolites such as lactate, acetate, and amino acids, or products derived from macromolecule degradation. Mathematical and

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Regulation of common neurological disorders by gut microbial metabolites

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Short Chain Fatty Acids /

The gut is connected to the CNS by immunological mediators, lymphocytes, neurotransmitters, microbes and microbial metabolites. A mounting body of evidence indicates that the microbiome exerts significant effects on immune cells and CNS cells. These effects frequently result in the suppression or exacerbation of inflammatory responses, the latter of which can lead to severe tissue

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The role of probiotics in nutritional health: probiotics as nutribiotics

Biomarkers, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The gut microbiota has gained importance through the years due to its significant influences on the maintenance of human health. A wide variety of microorganisms shape this gut microbiota, which preserves health with the modulation of the immune system, enhancement of the nutrients absorption, or the protection against pathogens’ colonization. The disruption of this microenvironment

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The Undeniable Link Between the Brain and Gut

Biomarkers, Constipation, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Nausea, heartburn, indigestion, constipation, andstomach pain are all kinds of gastrointestinal problems we have faced before. They are easy to dismissas merely an upset stomach, but this mentality couldbuild up and ultimately be detrimental to mental and physicalhealth. Improperly caring for the digestive system can lead toextensive intestinal health issues. The microbiome is a collectionof

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