Gut Permeability / Leaky Gut

The Gut Microbiota Influenced by the Intake of Probiotics and
Functional Foods with Prebiotics Can Sustain Wellness and
Alleviate Certain Ailments like Gut-Inflammation and
Colon-Cancer

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Permeability / Leaky Gut, Probiotics, Prebiotics and Symbiotics /

The gut microbiota is composed of several microbial strains, with diverse and variablecombinations in healthy and sick persons, changing at different stages of life. A healthy balancebetween host and gut microorganisms must be maintained in order to perform the normal physiological, metabolic, and immune functions and prevent disease development. Disturbances in the balanceof the gut […]

The Gut Microbiota Influenced by the Intake of Probiotics and
Functional Foods with Prebiotics Can Sustain Wellness and
Alleviate Certain Ailments like Gut-Inflammation and
Colon-Cancer Read More »

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management

A-Synuclein, Gut Dysbiosis, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The identification of Parkinson’s disease (PD) is mainly dependent on motorsymptoms, while the non-motor symptoms exist even decades ahead of the PDdiagnosis. According to Braak’s hypothesis, the enteric plexus is the first affectedsite during the pathological development of PD, and gastrointestinal (GI) symptomsappear during the onset of the disease. Although GI symptoms decrease the lifequality

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management Read More »

THE MICROBIOTA-GUT-BRAIN AXIS

A-Synuclein, Butyrate, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However,the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms withinand on our bodies) as one of the key regulators of gut-brain function and has led to the appreciationof the importance of a distinct microbiota-gut-brain axis.This axis

THE MICROBIOTA-GUT-BRAIN AXIS Read More »

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

A-Synuclein, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The cellular hallmarks of Parkinson’s disease (PD) are the loss of nigral dopaminergic neurons and the formation of α-synuclein-enriched Lewy bodies and Lewy neurites in the remaining neurons. Based on the topographic distribution of Lewy bodies established after autopsy of brains from PD patients, Braak and coworkers hypothesized that Lewy pathology primes in the enteric

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats Read More »

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Oral Microbiome, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Microbial alterations within the gut microbiome appear to be a common feature of individuals with Parkinson’sdisease (PD), providing further evidence for the role of the gut-brain axis in PD development. As a major site ofcontact with the environment, questions have emerged surrounding the cause and effect of alterations to the gutmicrobiome by environmental contaminants associated

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease Read More »

Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset

Gut Dysbiosis, Gut Permeability / Leaky Gut, Oral Microbiome /

We found increasing gut-dysbiosis with worsening symptoms in sALS patients and increasing oral-dysbiosis with worsening symptoms in bALS patients. Our findings support distinct microbial mechanisms underlying two ALS subtypes, which have been previously grouped together as a single disease. Our study suggests correcting gut-dysbiosis as a therapeutic strategy for sALS patients and correcting oral-dysbiosis as

Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset Read More »

Characteristics of gut microbiome, organic acid profiles and viral antibody indexes of
healthy Japanese with live Lacticaseibacillus detected in stool

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Probiotics, Prebiotics and Symbiotics /

To estimate the health-promoting effects of Lacticaseibacillus paracasei (previously Lactobacillus casei) strainShirota (LcS) that reached the lower gastrointestinal tract alive, we investigated the characteristics of gut microbiome,organic acid profiles, defecatory symptoms and serum viral antibody indexes of healthy Japanese adults between thegroup in whom live LcS was detected or not from stool. The β-diversity index

Characteristics of gut microbiome, organic acid profiles and viral antibody indexes of
healthy Japanese with live Lacticaseibacillus detected in stool Read More »

Parkinson’s disease: Are gut microbes involved?

Biomarkers, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

Parkinson’s disease (PD) isa common neurodegenerative disorder characterized by motor and gastrointestinal(GI) deficits. Despite its prevalence, the pathophysiology of PD is not wellunderstood. Recent studies highlight the role of gut microbiota in neurologicaldisorders. In this review, we summarize the potential role of gut microbiota inthe pathophysiology of PD. We first describe how gut microbiota can

Parkinson’s disease: Are gut microbes involved? Read More »

Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease is characterized by motor and non-motor symptoms, such as defects in the gut function, which may occur before the motor symptoms. To date, there are therapies that can improve these symptoms, but there is no cure to avoid the development or exacerbation of this disorder. Dysbiosis of gut microbiota could have a crucial

Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease Read More »

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The human body is full of an extensive number of commensal microbes, consisting of bacteria, viruses, and fungi, collectively termed the human microbiome. The initial acquisition of microbiota occurs from both the external and maternal environments, and the vast majority of them colonize the gastrointestinal tract (GIT). These microbial communities play a central role in

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders Read More »