Gut Permeability / Leaky Gut

The gut microbiome: implications for neurogenesis and neurological diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Short Chain Fatty Acids /

The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation of this disease. Microbiota analysis has revealed increased Enterobacteria and decreased Prevotella strains in patients with PD (Scheperjans et al., 2015). Another clinical study found that, compared with healthy controls, patients with PD exhibited decreases in a range of […]

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Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study

Biomarkers, Gut Dysbiosis, Gut Permeability / Leaky Gut, Lipopolysaccharides (LPS), Parkinson's Disease, Pre-PD, Zonulin /

Biomarkers that link a leaky gut and subsequent bacterial translocation to metabolic health were identified in this study. Especially zonulin may aid in monitoring a leaky gut and detecting individuals at risk for developing chronic metabolic diseases. CLICK TO REVIEW

Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study Read More »

Neurological disorders associated with impaired gut microbiota

Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Proinflammatory mediators such as iNOS, ROS, COX2 and NF-B are released by microglia, resulting in neuroinflammation in Alzheimer’s disease. It is becoming more widely recognized as a symptom of Autism Spectrum Disorder. The establishment of gut-brain psychology is expected to have a significant impact on psychology and related disciplines. CLICK TO REVIEW

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Improvement of colonic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides

Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

Inulin and GOS diets were associated with increased butyrate production and better anastomotic healing. Histological analysis revealed an enhanced mucosal continuity, and this was associated with an increased re-epithelialization of the wound as determined by increased epithelial proliferation. Collagen concentration in peri-anastomotic tissue was higher with inulin and GOS diets and MMP activity, a marker

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Dietary restrictions modulate the gut microbiota: Implications for health and disease

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

The data suggest that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression of several diseases such as obesity, diabetes, neurological diseases or inflammatory bowel disease. Finally, the relevance of the findings for clinical practice is evaluated and approaches for future research are proposed. CLICK TO REVIEW

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Comparison of bioactive constituents and effects on gut microbiota by in vitro fermentation between Ophicordyceps sinensis and Cordyceps militaris

Biomarkers, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Herbs & Spices, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

After in vitro digestion and anaerobic fermentation, both O. sinensis and C. militaris could modulate the gut microbiota composition through reducing the ratio of Firmicutes to Bacteroidetes. Moreover, this research demonstrated that O. sinensis had more positive effects on the intestinalhealth compared with C. militaris via decreasing the pH of gut environment, stimulating the production

Comparison of bioactive constituents and effects on gut microbiota by in vitro fermentation between Ophicordyceps sinensis and Cordyceps militaris Read More »

Is Gut Dysbiosis an Epicenter of Parkinson’s Disease?

Gut Dysbiosis, Gut Permeability / Leaky Gut /

Nevertheless, the scientific literature is overflowing with the remarkable observations supporting the role of dysbiosis in PD. Lack of specificity to differentially diagnose PD with non-PD or PD-plus syndrome, to identify highly precise drug targets and to develop therapeutic stratagems to encounter the disease on the basis of this approach, causes us to be open-minded

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The Gut-Brain Axis

Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

The concept of the gut-brain axis (GBA) has existed for more than 3 decades [1]. Gastrointestinal motor and sensory components send messages to the central nervous system (CNS), and the return response to the intestine is the definition of the GBA [2]. Nutrition affects microbiota colonization and gut metabolites, which can influence brain development and

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Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression

Ayahuasca, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

Additionally, it is known that, in periods of excessive activation of stress reactions, the immune system also plays an important role, negatively affecting the tightness of the intestinal barrier and intestinal microflora. In this review, we have summarized the role of the gut microbiota, its metabolites, and diet in susceptibility to depression. We also describe

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Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress‐induced depressive‐like behavior

Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

The gut‐microbiota‐brain axis is the most important complex and bidirectional pathway between the gastrointestinal tract and the central nervous system. This study investigated the potential of microbe‐induced gut‐to‐brain signaling to modulate the effect of stress on depressive‐like behavior, intestinal barrier, and neuroinflammation. Result showed that fecal microbiota transplantation increased the consumption of sucrose solutions and

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